Prostaglandin E synthase

prostaglandin-E synthase

human microsomal prostaglandin E synthase 1 with bound glutathione. PDB entry 3DWW[1]
Identifiers
EC number 5.3.99.3
CAS number 52227-79-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Prostaglandin E synthase (or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.[2][3]

The synthase generating PGE2 is a membrane-associated protein.

Biosynthesis of eicosanoids.

Isozymes

Humans express three prostaglandin-E synthase isozymes, each encoded by a separate gene:

prostaglandin E synthase (microsomal)
Identifiers
Symbol PTGES
Alt. symbols MGST1L1
Entrez 9536
HUGO 9599
OMIM 605172
RefSeq NM_004878
UniProt O14684
Other data
Locus Chr. 9 q34.3
prostaglandin E synthase 2 (microsomal)
Identifiers
Symbol PTGES2
Alt. symbols C9orf15
Entrez 80142
HUGO 17822
OMIM 608152
RefSeq NM_198939
UniProt Q9H7Z7
Other data
Locus Chr. 9 q34.12
prostaglandin E synthase 3 (cytosolic)
Identifiers
Symbol PTGES3
Alt. symbols p23, TEBP, cPGES
Entrez 10728
HUGO 16049
OMIM 607061
RefSeq NM_006601
UniProt Q15185
Other data
Locus Chr. 12 q13.13

References

  1. ↑ Jegerschold, C.; Pawelzik, S. -C.; Purhonen, P.; Bhakat, P.; Gheorghe, K. R.; Gyobu, N.; Mitsuoka, K.; Morgenstern, R.; Jakobsson, P. -J.; Hebert, H. (2008). "Structural basis for induced formation of the inflammatory mediator prostaglandin E2". Proceedings of the National Academy of Sciences. 105 (32): 11110–11115. PMC 2516235 Freely accessible. PMID 18682561. doi:10.1073/pnas.0802894105.
  2. ↑ Murakami M, Nakatani Y, Tanioka T, Kudo I (August 2002). "Prostaglandin E synthase". Prostaglandins Other Lipid Mediat. 68-69: 383–99. PMID 12432931. doi:10.1016/S0090-6980(02)00043-6.
  3. ↑ Park JY, Pillinger MH, Abramson SB (June 2006). "Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases". Clin. Immunol. 119 (3): 229–40. PMID 16540375. doi:10.1016/j.clim.2006.01.016.
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