PGDS
PGDS protein is a protein that in humans is encoded by the HPGDS gene.[5][6][7][8]
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.[8]
See also
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000163106 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029919 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O (Oct 1997). "Cloning and crystal structure of hematopoietic prostaglandin D synthase". Cell. 90 (6): 1085–95. PMID 9323136. doi:10.1016/S0092-8674(00)80374-8.
- ↑ Mahmud I, Ueda N, Yamaguchi H, Yamashita R, Yamamoto S, Kanaoka Y, Urade Y, Hayaishi O (Dec 1997). "Prostaglandin D synthase in human megakaryoblastic cells". J Biol Chem. 272 (45): 28263–6. PMID 9353279. doi:10.1074/jbc.272.45.28263.
- ↑ Jowsey IR, Thomson AM, Flanagan JU, Murdock PR, Moore GB, Meyer DJ, Murphy GJ, Smith SA, Hayes JD (Oct 2001). "Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases". Biochem J. 359 (Pt 3): 507–16. PMC 1222171
. PMID 11672424. doi:10.1042/0264-6021:3590507. - 1 2 "Entrez Gene: PGDS prostaglandin D2 synthase, hematopoietic".
Further reading
- Kanaoka Y, Urade Y (2004). "Hematopoietic prostaglandin D synthase.". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2-3): 163–7. PMID 12895599. doi:10.1016/S0952-3278(03)00077-2.
- Suzuki T, Watanabe K, Kanaoka Y, et al. (1998). "Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester.". Biochem. Biophys. Res. Commun. 241 (2): 288–93. PMID 9425264. doi:10.1006/bbrc.1997.7803.
- Tokugawa Y, Kunishige I, Kubota Y, et al. (1998). "Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma.". Biol. Reprod. 58 (2): 600–7. PMID 9475419. doi:10.1095/biolreprod58.2.600.
- Pinzar E, Kanaoka Y, Inui T, et al. (2000). "Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4903–7. PMC 18330 . PMID 10781097. doi:10.1073/pnas.090093997.
- Kanaoka Y, Fujimori K, Kikuno R, et al. (2000). "Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase.". Eur. J. Biochem. 267 (11): 3315–22. PMID 10824118. doi:10.1046/j.1432-1327.2000.01362.x.
- Fujimori K, Kanaoka Y, Sakaguchi Y, Urade Y (2001). "Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of the oct-1 element in the 5'-flanking region and the AP-2 element in the untranslated exon 1.". J. Biol. Chem. 275 (51): 40511–6. PMID 10998423. doi:10.1074/jbc.M007688200.
- Sui D, Wilson JE (2000). "Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase.". Arch. Biochem. Biophys. 382 (2): 262–74. PMID 11068878. doi:10.1006/abbi.2000.2019.
- Noguchi E, Shibasaki M, Kamioka M, et al. (2002). "New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes.". Clin. Exp. Allergy. 32 (1): 93–6. PMID 12002745. doi:10.1046/j.0022-0477.2001.01261.x.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Inoue T, Irikura D, Okazaki N, et al. (2003). "Mechanism of metal activation of human hematopoietic prostaglandin D synthase.". Nat. Struct. Biol. 10 (4): 291–6. PMID 12627223. doi:10.1038/nsb907.
- Ando M, Murakami Y, Kojima F, et al. (2003). "Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin.". Am. J. Respir. Cell Mol. Biol. 28 (5): 582–91. PMID 12707014. doi:10.1165/rcmb.2002-0162OC.
- Inoue T, Okano Y, Kado Y, et al. (2005). "First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase.". J. Biochem. 135 (3): 279–83. PMID 15113825. doi:10.1093/jb/mvh033.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
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