PDZK1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2EEI, 2EEJ, 2VSP, 3TMH, 4Q2P

Identifiers

Aliases

PDZK1, CAP70, CLAMP, NHERF-3, NHERF3, PDZD1, PDZ domain containing 1

External IDs

MGI: 1928901 HomoloGene: 1964 GeneCards: PDZK1

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	No data available	Start	145,670,852 bp^[1]
Band	No data available	End	145,708,148 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	No data available	Start	96,829,284 bp^[2]
Band	No data available	End	96,870,926 bp^[2]

Gene ontology
Molecular function	• scavenger receptor binding • protein complex binding • PDZ domain binding • protein binding • transporter activity
Cellular component	• membrane raft • brush border membrane • plasma membrane • extracellular exosome • apical plasma membrane • membrane • microvillus membrane
Biological process	• cell proliferation • carnitine transport • positive regulation of ion transmembrane transport • drug transport • regulation of anion transport • positive regulation of protein targeting to membrane • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5174


59020

Ensembl


ENSG00000174827


ENSMUSG00000038298

UniProt


Q5T2W1


Q9JIL4

RefSeq (mRNA)


NM_001201325 NM_001201326 NM_002614


NM_001146001 NM_021517

RefSeq (protein)


NP_001188254 NP_001188255 NP_002605


NP_001139473 NP_067492

Location (UCSC)

Chr 1: 145.67 – 145.71 Mb

Chr 1: 96.83 – 96.87 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene.^[5]^[6]

Interactions

PDZK1 has been shown to interact with:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174827 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038298 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Kocher O, Comella N, Tognazzi K, Brown LF (March 1998). "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains". Lab Invest. 78 (1): 117–25. PMID 9461128.
↑ "Entrez Gene: PDZK1 PDZ domain containing 1".
1 2 3 4 5 6 7 8 Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. PMID 14531806. doi:10.1046/j.1523-1755.2003.00266.x.
1 2 Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR (February 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. 278 (8): 6440–9. PMID 12471024. doi:10.1074/jbc.M211050200.
↑ Wang S, Yue H, Derin RB, Guggino WB, Li M (September 2000). "Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity". Cell. 103 (1): 169–79. PMID 11051556. doi:10.1016/s0092-8674(00)00096-9.
↑ Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H (October 2003). "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol. 285 (4): F784–91. PMID 12837682. doi:10.1152/ajprenal.00109.2003.
↑ Silver DL, Wang N, Vogel S (August 2003). "Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels". J. Biol. Chem. 278 (31): 28528–32. PMID 12754212. doi:10.1074/jbc.M304109200.
↑ Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers HH, Ullmann R, Horn D, Mundlos S (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. PMC 1785342 . PMID 17236129. doi:10.1086/510919.

White KE, Biber J, Murer H, Econs MJ (1999). "A PDZ domain-containing protein with homology to Diphor-1 maps to human chromosome 1q21". Ann. Hum. Genet. 62 (Pt 4): 287–90. PMID 9924606. doi:10.1046/j.1469-1809.1998.6240287.x.
Kocher O, Comella N, Gilchrist A, Pal R, Tognazzi K, Brown LF, Knoll JH (1999). "PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein". Lab. Invest. 79 (9): 1161–70. PMID 10496535.
Ikemoto M, Arai H, Feng D, Tanaka K, Aoki J, Dohmae N, Takio K, Adachi H, Tsujimoto M, Inoue K (2000). "Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I". Proc. Natl. Acad. Sci. U.S.A. 97 (12): 6538–43. PMC 18651 . PMID 10829064. doi:10.1073/pnas.100114397.
Wang S, Yue H, Derin RB, Guggino WB, Li M (2000). "Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity". Cell. 103 (1): 169–79. PMID 11051556. doi:10.1016/S0092-8674(00)00096-9.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Gisler SM, Stagljar I, Traebert M, Bacic D, Biber J, Murer H (2001). "Interaction of the type IIa Na/Pi cotransporter with PDZ proteins". J. Biol. Chem. 276 (12): 9206–13. PMID 11099500. doi:10.1074/jbc.M008745200.
Silver DL (2002). "A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver". J. Biol. Chem. 277 (37): 34042–7. PMID 12119305. doi:10.1074/jbc.M206584200.
Sellin L, Huber TB, Gerke P, Quack I, Pavenstädt H, Walz G (2003). "NEPH1 defines a novel family of podocin interacting proteins". FASEB J. 17 (1): 115–7. PMID 12424224. doi:10.1096/fj.02-0242fje.
Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR (2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. 278 (8): 6440–9. PMID 12471024. doi:10.1074/jbc.M211050200.
Hegedüs T, Sessler T, Scott R, Thelin W, Bakos E, Váradi A, Szabó K, Homolya L, Milgram SL, Sarkadi B (2003). "C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins". Biochem. Biophys. Res. Commun. 302 (3): 454–61. PMID 12615054. doi:10.1016/S0006-291X(03)00196-7.
Silver DL, Wang N, Vogel S (2003). "Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels". J. Biol. Chem. 278 (31): 28528–32. PMID 12754212. doi:10.1074/jbc.M304109200.
Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H (2003). "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol. 285 (4): F784–91. PMID 12837682. doi:10.1152/ajprenal.00109.2003.
Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. PMID 14531806. doi:10.1046/j.1523-1755.2003.00266.x.
Kocher O, Yesilaltay A, Cirovic C, Pal R, Rigotti A, Krieger M (2004). "Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism". J. Biol. Chem. 278 (52): 52820–5. PMID 14551195. doi:10.1074/jbc.M310482200.
Inoue J, Otsuki T, Hirasawa A, Imoto I, Matsuo Y, Shimizu S, Taniwaki M, Inazawa J (2004). "Overexpression of PDZK1 within the 1q12-q22 Amplicon Is Likely To Be Associated with Drug-Resistance Phenotype in Multiple Myeloma". Am. J. Pathol. 165 (1): 71–81. PMC 1618545 . PMID 15215163. doi:10.1016/S0002-9440(10)63276-2.
Anzai N, Miyazaki H, Noshiro R, Khamdang S, Chairoungdua A, Shin HJ, Enomoto A, Sakamoto S, Hirata T, Tomita K, Kanai Y, Endou H (2004). "The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus". J. Biol. Chem. 279 (44): 45942–50. PMID 15304510. doi:10.1074/jbc.M406724200.

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PDZK1

Interactions

Related gene problems

References

Further reading