PDE6G

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3JWR

Identifiers

Aliases

PDE6G, PDEG, RP57, phosphodiesterase 6G

External IDs

MGI: 97526 HomoloGene: 1955 GeneCards: PDE6G

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	No data available	Start	81,650,459 bp^[1]
Band	No data available	End	81,663,112 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	No data available	Start	120,447,605 bp^[2]
Band	No data available	End	120,453,500 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• enzyme inhibitor activity • spectrin binding • cGMP binding • protein binding • 3',5'-cyclic-GMP phosphodiesterase activity • 3',5'-cyclic-nucleotide phosphodiesterase activity • hydrolase activity
Cellular component	• plasma membrane • photoreceptor disc membrane
Biological process	• positive regulation of G-protein coupled receptor protein signaling pathway • activation of MAPK activity • positive regulation of epidermal growth factor receptor signaling pathway • visual perception • rhodopsin mediated signaling pathway • response to stimulus • regulation of rhodopsin mediated signaling pathway • negative regulation of catalytic activity • Wnt signaling pathway, calcium modulating pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5148


18588

Ensembl


ENSG00000185527


ENSMUSG00000025386

UniProt


P18545


P09174

RefSeq (mRNA)


NM_002602


NM_012065

RefSeq (protein)


NP_002593


NP_036197

Location (UCSC)

Chr 17: 81.65 – 81.66 Mb

Chr 17: 120.45 – 120.45 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.^[5]^[6]

Interactions

PDE6G has been shown to interact with Beta adrenergic receptor kinase^[7] and Src.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185527 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025386 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL (Apr 1990). "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene". Genomics. 6 (2): 272–83. PMID 2155175. doi:10.1016/0888-7543(90)90567-E.
↑ "Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma".
1 2 Wan, Kah Fei; Sambi Balwinder S; Tate Rothwelle; Waters Catherine; Pyne Nigel J (May 2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". J. Biol. Chem. United States. 278 (20): 18658–63. ISSN 0021-9258. PMID 12624098. doi:10.1074/jbc.M212103200.

Cotran PR, Bruns GA, Berson EL, Dryja TP (1992). "Genetic analysis of patients with retinitis pigmentosa using a cloned cDNA probe for the human gamma subunit of cyclic GMP phosphodiesterase.". Exp. Eye Res. 53 (5): 557–64. PMID 1683837. doi:10.1016/0014-4835(91)90213-X.
Piriev, N. I.; V. A. Purishko; N. V. Khramtsov; V. M. Lipkin (1991). "The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase" [The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase]. Doklady Akademii Nauk SSSR. 315 (1): 229–31. PMID 1965799.
Tuteja N, Danciger M, Klisak I, et al. (1990). "Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina.". Gene. 88 (2): 227–32. PMID 2161380. doi:10.1016/0378-1119(90)90035-P.
Piriev NI, Khramtsov NV, Lipkin VM (1995). "Cloning and characterization of the gene encoding the cGMP-phosphodiesterase gamma-subunit of human rod photoreceptor cells.". Gene. 151 (1–2): 297–301. PMID 7828894. doi:10.1016/0378-1119(94)90674-2.
Hahn LB, Berson EL, Dryja TP (1994). "Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa". Invest. Ophthalmol. Vis. Sci. 35 (3): 1077–82. PMID 8125719.
Dollfus H, Mattei MG, Rozet JM, et al. (1993). "Physical and genetic localization of the gamma subunit of the cyclic GMP phosphodiesterase on the long arm of chromosome 17 (17q25)". Genomics. 17 (2): 526–8. PMID 8406511. doi:10.1006/geno.1993.1364.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Wan KF, Sambi BS, Frame M, et al. (2001). "The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells". J. Biol. Chem. 276 (41): 37802–8. PMID 11502744. doi:10.1074/jbc.M105087200.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Wan KF, Sambi BS, Tate R, et al. (2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". J. Biol. Chem. 278 (20): 18658–63. PMID 12624098. doi:10.1074/jbc.M212103200.
Morin F, Vannier B, Houdart F, et al. (2003). "A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins". Mol. Vis. 9: 449–59. PMID 14502124.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.

External links

GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview

PDB gallery

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1fqj: CRYSTAL STRUCTURE OF THE HETEROTRIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, THE GAMMA SUBUNIT OF PHOSPHODIESTERASE AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(PDEGAMMA)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]

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PDE6G

Interactions

References

Further reading

External links