PCYT1B

PCYT1B

Identifiers

PCYT1B, CCTB, CTB, phosphate cytidylyltransferase 1, choline, beta

External IDs

MGI: 2147987 HomoloGene: 3564 GeneCards: PCYT1B

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	No data available	Start	24,558,087 bp^[1]
Band	No data available	End	24,672,677 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	No data available	Start	93,654,863 bp^[2]
Band	No data available	End	93,749,951 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• nucleotidyltransferase activity • catalytic activity • transferase activity • choline-phosphate cytidylyltransferase activity
Cellular component	• endoplasmic reticulum membrane • cytoplasm • endoplasmic reticulum
Biological process	• phospholipid biosynthetic process • phosphatidylcholine biosynthetic process • biosynthetic process • spermatogenesis • ovarian follicle development • lipid metabolic process • CDP-choline pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


9468


236899


ENSG00000102230


ENSMUSG00000035246


Q9Y5K3


Q811Q9

RefSeq (mRNA)


NM_001163264 NM_001163265 NM_004845


NM_177546 NM_211138

RefSeq (protein)


NP_001156736 NP_001156737 NP_004836


NP_808214 NP_997593

Location (UCSC)

Chr X: 24.56 – 24.67 Mb

Chr X: 93.65 – 93.75 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Choline-phosphate cytidylyltransferase B is an enzyme that in humans is encoded by the PCYT1B gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102230 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035246 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Lykidis A, Murti KG, Jackowski S (Jul 1998). "Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase". J Biol Chem. 273 (22): 14022–9. PMID 9593753. doi:10.1074/jbc.273.22.14022.
↑ "Entrez Gene: PCYT1B phosphate cytidylyltransferase 1, choline, beta".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. PMID 15345747. doi:10.1074/mcp.M400085-MCP200.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Llorca O, Martín-Benito J, Gómez-Puertas P, et al. (2002). "Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin". J. Struct. Biol. 135 (2): 205–18. PMID 11580270. doi:10.1006/jsbi.2001.4359.
McCormack EA, Llorca O, Carrascosa JL, et al. (2002). "Point mutations in a hinge linking the small and large domains of beta-actin result in trapped folding intermediates bound to cytosolic chaperonin CCT". J. Struct. Biol. 135 (2): 198–204. PMID 11580269. doi:10.1006/jsbi.2001.4385.
Lykidis A, Baburina I, Jackowski S (1999). "Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant". J. Biol. Chem. 274 (38): 26992–7001. PMID 10480912. doi:10.1074/jbc.274.38.26992.
Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. PMID 10409428. doi:10.1006/geno.1999.5855.

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