PCP4

PCP4
Identifiers
AliasesPCP4, PEP-19, Purkinje cell protein 4
External IDsMGI: 97509 HomoloGene: 4519 GeneCards: PCP4
Gene location (Human)
Chr.Chromosome 21 (human)[1]
BandNo data availableStart39,867,317 bp[1]
End39,929,397 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5121

18546

Ensembl

ENSG00000183036

ENSMUSG00000090223

UniProt

P48539

P63054

RefSeq (mRNA)

NM_006198

NM_008791

RefSeq (protein)

NP_006189

NP_032817

Location (UCSC)Chr 21: 39.87 – 39.93 MbChr 21: 96.47 – 96.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene.[5][6][7] Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM).[8] PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity.[8][9]

Function

PCP4 knockout mice have been reported to exhibit impaired locomotor learning and markedly altered synaptic plasticity in cerebellar Purkinje neurons.[8] PCP4 accelerates both the association and dissociation of calcium (Ca2+) with calmodulin (CaM), which is postulated to influence the activity of CaM-dependent enzymes, especially CaM kinase II (CaMK-II).[8][10][11]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183036 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090223 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Chen H, Bouras C, Antonarakis SE (Jan 1997). "Cloning of the cDNA for a human homolog of the rat PEP-19 gene and mapping to chromosome 21q22.2-q22.3". Hum Genet. 98 (6): 672–7. PMID 8931698. doi:10.1007/s004390050282.
  6. ↑ Cabin DE, Gardiner K, Reeves RH (Dec 1996). "Molecular genetic characterization and comparative mapping of the human PCP4 gene". Somat Cell Mol Genet. 22 (3): 167–75. PMID 8914602. doi:10.1007/BF02369907.
  7. ↑ "Entrez Gene: PCP4 Purkinje cell protein 4".
  8. 1 2 3 4 Wei P, Blundon JA, Rong Y, Zakharenko SS, Morgan JI (2011). "Impaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/PCP4-null mice". Mol. Cell. Biol. 31 (14): 2838–44. PMC 3133400 Freely accessible. PMID 21576365. doi:10.1128/MCB.05208-11.
  9. ↑ Sangameswaran L, Hempstead J, Morgan JI (1989). "Molecular cloning of a neuron-specific transcript and its regulation during normal and aberrant cerebellar development". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5651–5. PMC 297682 Freely accessible. PMID 2748608. doi:10.1073/pnas.86.14.5651.
  10. ↑ Putkey JA, Kleerekoper Q, Gaertner TR, Waxham MN (2004). "A new role for IQ motif proteins in regulating calmodulin function.". J. Biol. Chem. 278 (50): 49667–70. PMID 14551202. doi:10.1074/jbc.C300372200.
  11. ↑ Kleerekoper QK, Putkey JA (2009). "PEP-19, an intrinsically disordered regulator of calmodulin signaling". J. Biol. Chem. 284 (12): 7455–64. PMC 2658041 Freely accessible. PMID 19106096. doi:10.1074/jbc.M808067200.

Further reading

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