PCLKC
Protocadherin-24 is a protein that in humans is encoded by the PCDH24 gene.[5][6][7]
This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. The kidney-expressed gene product has a signal peptide, nine cadherin repeat domains and a unique cytoplasmic region. This protocadherin represents a new candidate for tumor suppression.[7]
Interactions
PCLKC has been shown to interact with MAST2.[6]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000074276 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034918 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Suzuki ST (Dec 2000). "Recent progress in protocadherin research". Exp Cell Res. 261 (1): 13–8. PMID 11082270. doi:10.1006/excr.2000.5039.
- 1 2 Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (Jul 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis. 23 (7): 1139–48. PMID 12117771. doi:10.1093/carcin/23.7.1139.
- 1 2 "Entrez Gene: PCLKC protocadherin LKC".
Further reading
- Yang LY, Wang W, Peng JX, et al. (2005). "Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma.". World J. Gastroenterol. 10 (24): 3569–73. PMID 15534908.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549. doi:10.1101/gr.6.9.807.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
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