PARVB

PARVB

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4EDL, 4EDM, 4EDN

Identifiers

PARVB, CGI-56, parvin beta

External IDs

MGI: 2153063 HomoloGene: 8342 GeneCards: PARVB

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	No data available	Start	43,999,211 bp^[1]
Band	No data available	End	44,172,949 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	No data available	Start	84,232,043 bp^[2]
Band	No data available	End	84,315,688 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• actin binding • protein binding
Cellular component	• cytoplasm • cytosol • cell junction • plasma membrane • cell projection • sarcomere • Z disc • cytoskeleton • membrane • focal adhesion • lamellipodium
Biological process	• actin cytoskeleton reorganization • cell adhesion • cell projection assembly • lamellipodium assembly • establishment or maintenance of cell polarity regulating cell shape
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


29780


170736


ENSG00000188677


ENSMUSG00000022438


Q9HBI1


Q9ES46

RefSeq (mRNA)


NM_001003828 NM_001243385 NM_001243386 NM_013327


NM_133167

RefSeq (protein)


NP_001003828 NP_001230314 NP_001230315 NP_037459


NP_573395

Location (UCSC)

Chr 22: 44 – 44.17 Mb

Chr 22: 84.23 – 84.32 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Beta-parvin is a protein that in humans is encoded by the PARVB gene.^[5]^[6]^[7]

Members of the parvin family, including PARVB, PARVA and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188677 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022438 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. PMC 310876 . PMID 10810093. doi:10.1101/gr.10.5.703.
↑ Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. PMID 11171322.
1 2 "Entrez Gene: PARVB parvin, beta".

Further reading

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature. 402 (6761): 489–95. PMID 10591208. doi:10.1038/990031.
Yamaji S, Suzuki A, Sugiyama Y, et al. (2001). "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction.". J. Cell Biol. 153 (6): 1251–64. PMC 2192033 . PMID 11402068. doi:10.1083/jcb.153.6.1251.
Korenbaum E, Olski TM, Noegel AA (2002). "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans.". Gene. 279 (1): 69–79. PMID 11722847. doi:10.1016/S0378-1119(01)00743-0.
Yamaji S, Suzuki A, Kanamori H, et al. (2002). "Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation.". Biochem. Biophys. Res. Commun. 297 (5): 1324–31. PMID 12372433. doi:10.1016/S0006-291X(02)02381-1.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling.". Hum. Mol. Genet. 12 (2): 155–67. PMID 12499396. doi:10.1093/hmg/ddg019.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22.". Genome Res. 13 (1): 27–36. PMC 430954 . PMID 12529303. doi:10.1101/gr.695703.
Mishima W, Suzuki A, Yamaji S, et al. (2004). "The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor.". Genes Cells. 9 (3): 193–204. PMID 15005707. doi:10.1111/j.1356-9597.2004.00717.x.
Yamaji S, Suzuki A, Kanamori H, et al. (2004). "Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction.". J. Cell Biol. 165 (4): 539–51. PMC 2172344 . PMID 15159419. doi:10.1083/jcb.200308141.
Zhang Y, Chen K, Tu Y, Wu C (2004). "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival.". J. Biol. Chem. 279 (40): 41695–705. PMID 15284246. doi:10.1074/jbc.M401563200.
Mongroo PS, Johnstone CN, Naruszewicz I, et al. (2004). "Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer.". Oncogene. 23 (55): 8959–70. PMID 15467740. doi:10.1038/sj.onc.1208112.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Matsuda C, Kameyama K, Tagawa K, et al. (2005). "Dysferlin interacts with affixin (beta-parvin) at the sarcolemma.". J. Neuropathol. Exp. Neurol. 64 (4): 334–40. PMID 15835269.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

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