PARP4

Identifiers

PARP4, ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193, poly(ADP-ribose) polymerase family member 4

External IDs

MGI: 2685589 HomoloGene: 124423 GeneCards: PARP4

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	No data available	Start	24,420,926 bp^[1]
Band	No data available	End	24,512,810 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	No data available	Start	56,575,619 bp^[2]
Band	No data available	End	56,659,794 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity • DNA binding • transferase activity, transferring glycosyl groups • protein binding • enzyme binding • NAD+ ADP-ribosyltransferase activity
Cellular component	• cytoplasm • membrane • spindle • intracellular ribonucleoprotein complex • spindle microtubule • extracellular exosome • cytoskeleton • nucleus • cytosol
Biological process	• protein ADP-ribosylation • cell death • cellular response to DNA damage stimulus • cellular protein modification process • inflammatory response • DNA repair • response to drug • regulation of telomerase activity • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


143


328417

Ensembl


ENSG00000102699


ENSMUSG00000054509

UniProt


Q9UKK3


n/a

RefSeq (mRNA)


NM_006437


NM_001145978

RefSeq (protein)


NP_006428


n/a

Location (UCSC)

Chr 13: 24.42 – 24.51 Mb

Chr 13: 56.58 – 56.66 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.^[5]^[6]

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.^[6]

Interactions

PARP4 has been shown to interact with Major vault protein.^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102699 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054509 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Still IH, Vince P, Cowell JK (Mar 2000). "Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein". Genomics. 62 (3): 533–6. PMID 10644454. doi:10.1006/geno.1999.6024.
1 2 "Entrez Gene: PARP4 poly (ADP-ribose) polymerase family, member 4".
↑ van Zon, Arend; Mossink Marieke H; Schoester Martijn; Scheffer George L; Scheper Rik J; Sonneveld Pieter; Wiemer Erik A C (Mar 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. United States. 291 (3): 535–41. ISSN 0006-291X. PMID 11855821. doi:10.1006/bbrc.2002.6472.
↑ Kickhoefer, V A; Siva A C; Kedersha N L; Inman E M; Ruland C; Streuli M; Rome L H (Sep 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". J. Cell Biol. UNITED STATES. 146 (5): 917–28. ISSN 0021-9525. PMC 2169495 . PMID 10477748. doi:10.1083/jcb.146.5.917.

Jean L, Risler JL, Nagase T, et al. (1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. PMID 10100603. doi:10.1016/S0014-5793(99)00173-8.
Soldani C, Scovassi AI (2003). "Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update.". Apoptosis. 7 (4): 321–8. PMID 12101391. doi:10.1023/A:1016119328968.
Bouchard VJ, Rouleau M, Poirier GG (2003). "PARP-1, a determinant of cell survival in response to DNA damage.". Exp. Hematol. 31 (6): 446–54. PMID 12829019. doi:10.1016/S0301-472X(03)00083-3.
Soares MB, Bonaldo MF, Jelene P, et al. (1994). "Construction and characterization of a normalized cDNA library.". Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9228–32. PMC 44785 . PMID 7937745. doi:10.1073/pnas.91.20.9228.
Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. PMID 8724849. doi:10.1093/dnares/3.1.17.
Kickhoefer VA, Siva AC, Kedersha NL, et al. (1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase.". J. Cell Biol. 146 (5): 917–28. PMC 2169495 . PMID 10477748. doi:10.1083/jcb.146.5.917.
Kickhoefer VA, Stephen AG, Harrington L, et al. (2000). "Vaults and telomerase share a common subunit, TEP1.". J. Biol. Chem. 274 (46): 32712–7. PMID 10551828. doi:10.1074/jbc.274.46.32712.
Siva AC, Raval-Fernandes S, Stephen AG, et al. (2001). "Up-regulation of vaults may be necessary but not sufficient for multidrug resistance.". Int. J. Cancer. 92 (2): 195–202. PMID 11291045. doi:10.1002/1097-0215(200102)9999:9999<::AID-IJC1168>3.0.CO;2-7.
van Zon A, Mossink MH, Schoester M, et al. (2001). "Multiple human vault RNAs. Expression and association with the vault complex.". J. Biol. Chem. 276 (40): 37715–21. PMID 11479319. doi:10.1074/jbc.M106055200.
van Zon A, Mossink MH, Schoester M, et al. (2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly.". Biochem. Biophys. Res. Commun. 291 (3): 535–41. PMID 11855821. doi:10.1006/bbrc.2002.6472.
Mazzon E, Dugo L, Li JH, et al. (2002). "GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat.". Biochem. Pharmacol. 64 (2): 327–37. PMID 12123754. doi:10.1016/S0006-2952(02)01075-4.
Liu TJ, Lin SY, Chau YP (2002). "Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells.". Toxicol. Appl. Pharmacol. 182 (2): 116–25. PMID 12140175. doi:10.1006/taap.2002.9438.
Nie Z, Phenix BN, Lum JJ, et al. (2003). "HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation.". Cell Death Differ. 9 (11): 1172–84. PMID 12404116. doi:10.1038/sj.cdd.4401094.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature. 428 (6982): 522–8. PMC 2665288 . PMID 15057823. doi:10.1038/nature02379.
Liu Y, Snow BE, Kickhoefer VA, et al. (2004). "Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo.". Mol. Cell. Biol. 24 (12): 5314–23. PMC 419898 . PMID 15169895. doi:10.1128/MCB.24.12.5314-5323.2004.

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PARP4

Interactions

References

Further reading