PARG

PARG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPARG, PARG99, poly(ADP-ribose) glycohydrolase
External IDsMGI: 1347094 HomoloGene: 50532 GeneCards: PARG
Gene location (Human)
Chr.Chromosome 10 (human)[1]
BandNo data availableStart49,818,279 bp[1]
End49,970,203 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8505

26430

Ensembl

ENSG00000227345

ENSMUSG00000021911

UniProt

Q86W56

O88622

RefSeq (mRNA)

NM_001303486
NM_001303487
NM_001303489
NM_003631
NM_001324381

NM_011960

RefSeq (protein)

NP_001290415
NP_001290416
NP_001290418
NP_001311310
NP_003622

NP_036090

Location (UCSC)Chr 10: 49.82 – 49.97 MbChr 10: 32.2 – 32.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poly (ADP-ribose) glycohydrolase is an enzyme that in humans is encoded by the PARG gene.[5][6][7]

Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly (ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000227345 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021911 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: Poly (ADP-ribose) glycohydrolase". Retrieved 2011-11-08.
  6. ↑ Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK (May 1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". J. Biol. Chem. 272 (18): 11895–901. PMID 9115250. doi:10.1074/jbc.272.18.11895.
  7. ↑ Amé JC, Apiou F, Jacobson EL, Jacobson MK (1999). "Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization". Cytogenet. Cell Genet. 85 (3-4): 269–70. PMID 10449915. doi:10.1159/000015310.

Further reading

  • Affar, E. B.; Germain, M.; Winstall, E.; Vodenicharov, M.; Shah, R. G.; Salvesen, G. S.; Poirier, G. G. (2000). "Caspase-3-mediated Processing of Poly(ADP-ribose) Glycohydrolase during Apoptosis". Journal of Biological Chemistry. 276 (4): 2935–2942. PMID 11053413. doi:10.1074/jbc.M007269200. 
  • Ohashi, S.; Kanai, M.; Hanai, S.; Uchiumi, F.; Maruta, H.; Tanuma, S.; Miwa, M. (2003). "Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells". Biochemical and Biophysical Research Communications. 307 (4): 915–921. PMID 12878198. doi:10.1016/S0006-291X(03)01272-5. 
  • Meyer, R. G.; Meyer-Ficca, M. L.; Jacobson, E. L.; Jacobson, M. K. (2003). "Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23)". Gene. 314: 181–190. PMID 14527731. doi:10.1016/S0378-1119(03)00738-8. 
  • Golovanov, A. P.; Barillà, D.; Golovanova, M.; Hayes, F.; Lian, L. Y. (2003). "ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure". Molecular Microbiology. 50 (4): 1141–1153. PMID 14622405. doi:10.1046/j.1365-2958.2003.03750.x. 
  • Keil, C.; Petermann, E.; Oei, S. L. (2004). "Tannins elevate the level of poly(ADP–ribose) in HeLa cell extracts". Archives of Biochemistry and Biophysics. 425 (1): 115–121. PMID 15081900. doi:10.1016/j.abb.2004.02.024. 
  • Meyer-Ficca, M. L.; Meyer, R. G.; Coyle, D. L.; Jacobson, E. L.; Jacobson, M. K. (2004). "Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments". Experimental Cell Research. 297 (2): 521–532. PMID 15212953. doi:10.1016/j.yexcr.2004.03.050. 
  • Putt, K. S.; Hergenrother, P. J. (2004). "A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): Application to inhibitor identification and evaluation". Analytical Biochemistry. 333 (2): 256–264. PMID 15450800. doi:10.1016/j.ab.2004.04.032. 
  • Bonicalzi, M. -E.; Haince, J. -F.; Droit, A.; Poirier, G. G. (2005). "Poly-ADP-ribosylation in health and disease". CMLS Cellular and Molecular Life Sciences. 62 (7–8): 739–750. PMID 15868399. doi:10.1007/s00018-004-4505-1. 
  • Bonicalzi, M. È.; Gagné, J. P.; Gagné, P.; Ouellet, M. È.; Hendzel, M. J.; Poirier, G. G. (2005). "Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles". Biochemical Journal. 392 (3): 499–509. PMC 1316289 Freely accessible. PMID 16117724. doi:10.1042/BJ20050792. 

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