PABPC3

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
4IVE

Identifiers

Aliases

PABPC3, PABP3, PABPL3, tPABP, poly(A) binding protein cytoplasmic 3

External IDs

HomoloGene: 118007 GeneCards: PABPC3

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	No data available	Start	25,095,868 bp^[1]
Band	No data available	End	25,099,254 bp^[1]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• poly(A) binding • RNA binding • nucleic acid binding
Cellular component	• cytoplasm • extracellular exosome • cytosol
Biological process	• mRNA metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5042


n/a

Ensembl


ENSG00000151846


n/a

UniProt


Q9H361


n/a

RefSeq (mRNA)


NM_030979


n/a

RefSeq (protein)


NP_112241


n/a

Location (UCSC)

Chr 13: 25.1 – 25.1 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Polyadenylate-binding protein 3 is a protein that in humans is encoded by the PABPC3 gene.^[3]^[4]^[5]

Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM]^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151846 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ Morris CM, Bodger MP (Mar 1993). "Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization". Genomics. 15 (1): 209–11. PMID 8432538. doi:10.1006/geno.1993.1037.
↑ Feral C, Mattei MG, Pawlak A, Guellaen G (Nov 1999). "Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes". Hum Genet. 105 (4): 347–53. PMC 1865476 . PMID 10543404. doi:10.1007/s004390051113.
1 2 "Entrez Gene: PABPC3 poly(A) binding protein, cytoplasmic 3".

Marques AC, Dupanloup I, Vinckenbosch N, et al. (2006). "Emergence of young human genes after a burst of retroposition in primates.". PLoS Biol. 3 (11): e357. PMC 1251493 . PMID 16201836. doi:10.1371/journal.pbio.0030357.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Féral C, Guellaën G, Pawlak A (2002). "Human testis expresses a specific poly(A)-binding protein.". Nucleic Acids Res. 29 (9): 1872–83. PMC 37253 . PMID 11328870. doi:10.1093/nar/29.9.1872.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Hoshino S, Imai M, Kobayashi T, et al. (1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.". J. Biol. Chem. 274 (24): 16677–80. PMID 10358005. doi:10.1074/jbc.274.24.16677.

PDB gallery

1g9l: SOLUTION STRUCTURE OF THE PABC DOMAIN OF HUMAN POLY(A) BINDING PROTEIN

1jgn: Solution structure of the C-terminal PABC domain of human poly(A)-binding protein in complex with the peptide from Paip2

1jh4: Solution structure of the C-terminal PABC domain of human poly(A)-binding protein in complex with the peptide from Paip1

2d9p: Solution structure of RNA binding domain 4 in Polyadenylation binding protein 3

RNA-binding proteins

Butyrate response factor 1
Fragile X mental retardation protein
Rev
hu paraneoplastic encephalomyelitis antigens
mRNA cleavage and polyadenylation factors (Cleavage and polyadenylation specificity factor
Cleavage stimulation factor)
host factor 1 protein
Aconitase (ACO1
ACO2)
nuclear factor 90 proteins (ILF2)
Poly(A)-binding protein (PABPC1
PABPC3
PABPC4)
polypyrimidine tract-binding protein
ribonucleoprotein
RNA cap-binding protein (Cap binding complex
EIF4E
EIF4G1)
SMN complex proteins (SMN1
SMN2
DDX20)

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PABPC3

References

Further reading