Organic cation transport proteins

An organic cation transport protein mediates the transport of organic cations across the cell membrane. These proteins are members of the solute carrier family, subfamily 22. This family of proteins can also transport zwitterions and anions, though it is a different subfamily of solute carrier proteins than the organic anion transporters.

Proteins

AbbreviationProtein nameLocationTransported solute(s)Associated disorder(s)
SLC22A1Solute carrier family 22 member 1Liver, Brain (Cerebellum)
SLC22A2Solute carrier family 22 member 2Primarily in kidney, also in brain
SLC22A3Solute carrier family 22 member 3Brain and kidney Histamine Dopamine Serotonin Norepinephrine MPP+
SLC22A4Solute carrier family 22 member 4 Sodium ion and Ergothioneine
SLC22A5Solute carrier family 22 member 5 Primary carnitine deficiency
SLC22A6Solute carrier family 22 member 6
SLC22A7Solute carrier family 22 member 7
SLC22A8Solute carrier family 22 member 8
SLC22A9Solute carrier family 22 member 9
SLC22A10Solute carrier family 22 member 10
SLC22A11Solute carrier family 22 member 11
SLC22A12Solute carrier family 22 member 12KidneyUric acidHyperuricemia and hypouricemia
SLC22A13Solute carrier family 22 member 13
SLC22A14Solute carrier family 22 member 14
SLC22A15Solute carrier family 22 member 15
SLC22A16Solute carrier family 22 member 16
SLC22A17Solute carrier family 22 member 17
SLC22A18Solute carrier family 22 member 18 Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer
SLC22A19Solute carrier family 22 member 19
SLC22A20Solute carrier family 22 member 20
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