Oncostatin M receptor
Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene.[5][6]
OSMR is a member of the type I cytokine receptor family. This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.[5]
Clinical significance
The oncostatin M receptor is associated with primary cutaneous amyloidosis.[7]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000145623 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022146 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- 1 2 "Entrez Gene: oncostatin M receptor".
- ↑ Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. 271 (51): 32635–43. PMID 8999038. doi:10.1074/jbc.271.51.32635.
- ↑ Arita K, South AP, Hans-Filho G, et al. (January 2008). "Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis". Am. J. Hum. Genet. 82 (1): 73–80. PMC 2253984
. PMID 18179886. doi:10.1016/j.ajhg.2007.09.002.
External links
- Oncostatin M Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
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