OSCAR (gene)

OSCAR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOSCAR, PIGR3, PIgR-3, osteoclast associated, immunoglobulin-like receptor
External IDsMGI: 2179720 HomoloGene: 77042 GeneCards: OSCAR
Gene location (Human)
Chr.Chromosome 19 (human)[1]
BandNo data availableStart54,094,668 bp[1]
End54,102,692 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

126014

232790

Ensembl

ENSMUSG00000054594

UniProt

Q8IYS5

Q8VBT3

RefSeq (mRNA)

NM_001290377
NM_175632

RefSeq (protein)

NP_001277306
NP_783440

Location (UCSC)Chr 19: 54.09 – 54.1 MbChr 19: 3.61 – 3.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Osteoclast-associated immunoglobulin-like receptor is a protein that in humans is encoded by the OSCAR gene.[5][6]

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. 1 2 3 ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 GRCh38: Ensembl release 89: ENSG00000277088, ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054594 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Kim N, Takami M, Rho J, Josien R, Choi Y (Jan 2002). "A novel member of the leukocyte receptor complex regulates osteoclast differentiation". J Exp Med. 195 (2): 201–9. PMC 2193610 Freely accessible. PMID 11805147. doi:10.1084/jem.20011681.
  6. 1 2 "Entrez Gene: OSCAR osteoclast-associated receptor".

Further reading

  • Pupello DF, Lipton M, Shumway NE (1976). "An unusual case of a bullet embolus.". The Journal of the Florida Medical Association. 62 (11): 51. PMID 1185147. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 Freely accessible. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Merck E, Gaillard C, Gorman DM, et al. (2004). "OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells.". Blood. 104 (5): 1386–95. PMID 15155468. doi:10.1182/blood-2004-03-0850. 
  • Merck E, de Saint-Vis B, Scuiller M, et al. (2005). "Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses.". Blood. 105 (9): 3623–32. PMID 15650060. doi:10.1182/blood-2004-07-2809. 
  • Tenca C, Merlo A, Merck E, et al. (2005). "CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells.". J. Immunol. 174 (11): 6757–63. PMID 15905516. doi:10.4049/jimmunol.174.11.6757. 
  • Kim GS, Koh JM, Chang JS, et al. (2005). "Association of the OSCAR promoter polymorphism with BMD in postmenopausal women.". J. Bone Miner. Res. 20 (8): 1342–8. PMID 16007331. doi:10.1359/JBMR.050320. 
  • Kim K, Kim JH, Lee J, et al. (2005). "Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.". J. Biol. Chem. 280 (42): 35209–16. PMID 16109714. doi:10.1074/jbc.M505815200. 
  • Merck E, Gaillard C, Scuiller M, et al. (2006). "Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils.". J. Immunol. 176 (5): 3149–56. PMID 16493074. doi:10.4049/jimmunol.176.5.3149. 


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