ONECUT1

ONECUT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S7E
Identifiers
Aliases	ONECUT1, HNF-6, HNF6, HNF6A, one cut homeobox 1
External IDs	MGI: 1196423 HomoloGene: 3309 GeneCards: ONECUT1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band No data available Start 52,756,989 bp[1] End 52,791,078 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band No data available Start 74,861,921 bp[2] End 74,891,781 bp[2]
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Cellular component • nucleus Biological process • Notch signaling pathway • epithelial cell development • cell differentiation • cell fate commitment • endoderm development • regulation of transcription, DNA-templated • positive regulation of cell migration • regulation of transcription from RNA polymerase II promoter • anatomical structure morphogenesis • negative regulation of transforming growth factor beta receptor signaling pathway • spleen development • transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of cell-matrix adhesion • glucose metabolic process • pancreas development • liver development • B cell differentiation • positive regulation of transcription from RNA polymerase II promoter • system development • endocrine pancreas development • cilium morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3175	15379
Ensembl	ENSG00000169856	ENSMUSG00000043013
UniProt	Q9UBC0	O08755
RefSeq (mRNA)	NM_004498	NM_008262
RefSeq (protein)	NP_004489	NP_032288
Location (UCSC)	Chr 15: 52.76 – 52.79 Mb	Chr 15: 74.86 – 74.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. ^[5]

Function

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.