OLR1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1YPO, 1YPQ, 1YPU, 1YXJ, 1YXK, 3VLG

Identifiers

Aliases

OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1, oxidized low density lipoprotein receptor 1

External IDs

MGI: 1261434 HomoloGene: 1910 GeneCards: OLR1

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	No data available	Start	10,158,301 bp^[1]
Band	No data available	End	10,172,138 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	No data available	Start	129,485,244 bp^[2]
Band	No data available	End	129,507,165 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• low-density lipoprotein receptor activity • protein binding • carbohydrate binding
Cellular component	• integral component of membrane • membrane • intracellular membrane-bounded organelle • receptor complex • plasma membrane • integral component of plasma membrane • nucleoplasm • extracellular region • membrane raft • extracellular exosome • specific granule membrane • tertiary granule membrane
Biological process	• immune system process • receptor-mediated endocytosis • blood circulation • proteolysis • cell adhesion • inflammatory response • leukocyte migration • neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4973


108078

Ensembl


ENSG00000173391


ENSMUSG00000030162

UniProt


P78380


Q9EQ09

RefSeq (mRNA)


NM_001172632 NM_001172633 NM_002543


NM_001301094 NM_001301096 NM_138648

RefSeq (protein)


NP_001166103 NP_001166104 NP_002534


NP_001288023 NP_001288025 NP_619589

Location (UCSC)

Chr 12: 10.16 – 10.17 Mb

Chr 12: 129.49 – 129.51 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.^[5]^[6]

Function

LOX-1 is a receptor protein which belongs to the C-type lectin superfamily. Its gene is regulated through the cyclic AMP signaling pathway. The protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor.^[6]

Clinical significance

Mutations of the OLR1 gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease.^[6] When applied to human macrophage-derived foam cells in vitro, the dietary supplement berberine inhibits the expression of the ORL1 gene in response to oxidized low-density lipoprotein cholesterol,^[7] but this has not yet been demonstrated in a living animal or human.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000173391 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030162 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Li X, Bouzyk MM, Wang X (Nov 1998). "Assignment of the human oxidized low-density lipoprotein receptor gene (OLR1) to chromosome 12p13.1→p12.3, and identification of a polymorphic CA-repeat marker in the OLR1 gene". Cytogenet Cell Genet. 82 (1–2): 34–6. PMID 9763655. doi:10.1159/000015059.
1 2 3 "Entrez Gene: OLR1 oxidized low density lipoprotein (lectin-like) receptor 1".
↑ Guan S, Wang B, Li W, Guan J, Fang X (2010). "Effects of berberine on expression of LOX-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL". Am J Chin Med. 38 (6): 1161–9. PMID 21061468. doi:10.1142/s0192415x10008548.

Sawamura T (2002). "[Molecular identification of LOX-1 and analysis of its pathophysiological role]". Nippon Yakurigaku Zasshi. 119 (3): 145–54. PMID 11915516. doi:10.1254/fpj.119.145.
Mehta JL, Li D (2002). "Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor". J. Am. Coll. Cardiol. 39 (9): 1429–35. PMID 11985903. doi:10.1016/S0735-1097(02)01803-X.
Sawamura T (2002). "[LOX-1: the oxidized LDL receptor expressed in vascular endothelial cells]". Seikagaku. 74 (5): 365–76. PMID 12073608.
Ando K, Fujita T (2005). "Role of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the development of hypertensive organ damage". Clin. Exp. Nephrol. 8 (3): 178–82. PMID 15480893. doi:10.1007/s10157-004-0288-9.
Sawamura T, Kume N, Aoyama T, et al. (1997). "An endothelial receptor for oxidized low-density lipoprotein". Nature. 386 (6620): 73–7. PMID 9052782. doi:10.1038/386073a0.
Yoshida H, Kondratenko N, Green S, et al. (1998). "Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor". Biochem. J. 334 ( Pt 1) (Pt 1): 9–13. PMC 1219654 . PMID 9693095.
Mehta JL, Li DY (1998). "Identification and autoregulation of receptor for OX-LDL in cultured human coronary artery endothelial cells". Biochem. Biophys. Res. Commun. 248 (3): 511–4. PMID 9703956. doi:10.1006/bbrc.1998.9004.
Yamanaka S, Zhang XY, Miura K, et al. (1999). "The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile". Genomics. 54 (2): 191–9. PMID 9828121. doi:10.1006/geno.1998.5561.
Nagase M, Abe J, Takahashi K, et al. (1999). "Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene". J. Biol. Chem. 273 (50): 33702–7. PMID 9837956. doi:10.1074/jbc.273.50.33702.
Draude G, Hrboticky N, Lorenz RL (1999). "The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin". Biochem. Pharmacol. 57 (4): 383–6. PMID 9933026. doi:10.1016/S0006-2952(98)00313-X.
Aoyama T, Sawamura T, Furutani Y, et al. (1999). "Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene". Biochem. J. 339 ( Pt 1) (Pt 1): 177–84. PMC 1220142 . PMID 10085242. doi:10.1042/0264-6021:3390177.
Li DY, Zhang YC, Philips MI, et al. (1999). "Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation". Circ. Res. 84 (9): 1043–9. PMID 10325241. doi:10.1161/01.res.84.9.1043.
Kataoka H, Kume N, Miyamoto S, et al. (1999). "Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions". Circulation. 99 (24): 3110–7. PMID 10377073. doi:10.1161/01.cir.99.24.3110.
Li D, Saldeen T, Romeo F, Mehta JL (2000). "Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells: the potential role of transcription factor NF-kappaB". Circulation. 102 (16): 1970–6. PMID 11034947. doi:10.1161/01.cir.102.16.1970.
Bull C, Sobanov Y, Röhrdanz B, et al. (2001). "The centromeric part of the human NK gene complex: linkage of LOX-1 and LY49L with the CD94/NKG2 region". Genes Immun. 1 (4): 280–7. PMID 11196705. doi:10.1038/sj.gene.6363678.
Shi X, Niimi S, Ohtani T, Machida S (2001). "Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor". J. Cell. Sci. 114 (Pt 7): 1273–82. PMID 11256994.
Chen M, Narumiya S, Masaki T, Sawamura T (2001). "Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding". Biochem. J. 355 (Pt 2): 289–96. PMC 1221738 . PMID 11284714. doi:10.1042/0264-6021:3550289.
Tanimoto A, Murata Y, Nomaguchi M, et al. (2001). "Histamine increases the expression of LOX-1 via H2 receptor in human monocytic THP-1 cells". FEBS Lett. 508 (3): 345–9. PMID 11728449. doi:10.1016/S0014-5793(01)03073-3.
Sobanov Y, Bernreiter A, Derdak S, et al. (2002). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur. J. Immunol. 31 (12): 3493–503. PMID 11745369. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9.

PDB gallery

1ypo: Human Oxidized Low Density Lipoprotein Receptor LOX-1 P3 1 21 Space Group

1ypq: Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex

1ypu: Human Oxidized Low Density Lipoprotein Receptor LOX-1 C2 Space Group

1yxj: Crystal structure of human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) at low pH

1yxk: Crystal structure of human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) disulfide-linked dimer

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OLR1

Function

Clinical significance

References

Further reading