OGFOD1

OGFOD1
Available structures
PDBOrtholog search: Q3U0K8%20or%20Q8N543%20or%20 Q3U0K8%20or%20H3BR79 PDBe Q3U0K8,Q8N543, Q3U0K8,H3BR79 RCSB
Identifiers
AliasesOGFOD1, TPA1, 2-oxoglutarate and iron dependent oxygenase domain containing 1
External IDsMGI: 2442978 HomoloGene: 41238 GeneCards: OGFOD1
Gene location (Human)
Chr.Chromosome 16 (human)[1]
BandNo data availableStart56,451,490 bp[1]
End56,479,100 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

55239

270086

Ensembl

ENSG00000087263

ENSMUSG00000033009

UniProt

Q8N543

Q8N543

RefSeq (mRNA)

NM_001093757
NM_177767

RefSeq (protein)
Location (UCSC)Chr 16: 56.45 – 56.48 MbChr 16: 94.04 – 94.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

2-oxoglutarate and iron-dependent oxygenase domain containing 1, also known as OGFOD1, is a human gene.[5]

Model organisms

Model organisms have been used in the study of OGFOD1 function. A conditional knockout mouse line, called Ogfod1tm1a(KOMP)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[12][13][14] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty five tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000087263 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033009 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: 2-oxoglutarate and iron-dependent oxygenase domain containing 1". Retrieved 2011-08-30.
  6. ↑ "Salmonella infection data for Ogfod1". Wellcome Trust Sanger Institute.
  7. ↑ "Citrobacter infection data for Ogfod1". Wellcome Trust Sanger Institute.
  8. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  9. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  10. ↑ "International Knockout Mouse Consortium".
  11. ↑ "Mouse Genome Informatics".
  12. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. PMC 3572410 Freely accessible. PMID 21677750. doi:10.1038/nature10163.
  13. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a.
  14. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018.
  15. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. PMC 3218837 Freely accessible. PMID 21722353. doi:10.1186/gb-2011-12-6-224.

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.