ODC1

ODC1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2OO0, 4ZGY, 5BWA, 1D7K, 2ON3

Identifiers

ODC1, ODC, ornithine decarboxylase 1

External IDs

MGI: 97402 HomoloGene: 1906 GeneCards: ODC1

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	No data available	Start	10,439,968 bp^[1]
Band	No data available	End	10,448,504 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	No data available	Start	17,544,794 bp^[2]
Band	No data available	End	17,551,505 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• ornithine decarboxylase activity • protein binding • protein homodimerization activity • carboxy-lyase activity • catalytic activity • lyase activity
Cellular component	• perinuclear region of cytoplasm • cytosol • cytoplasm
Biological process	• putrescine biosynthetic process • polyamine biosynthetic process • response to virus • polyamine metabolic process • regulation of cellular amino acid metabolic process • positive regulation of cell proliferation • kidney development • regulation of protein catabolic process • putrescine biosynthetic process from ornithine
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


4953


18263


ENSG00000115758


ENSMUSG00000011179


P11926


P00860

RefSeq (mRNA)


NM_002539 NM_001287188 NM_001287189 NM_001287190


NM_013614

RefSeq (protein)


NP_001274117 NP_001274118 NP_001274119 NP_002530


NP_038642

Location (UCSC)

Chr 2: 10.44 – 10.45 Mb

Chr 2: 17.54 – 17.55 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Ornithine decarboxylase is an enzyme that in humans is encoded by the ODC1 gene.

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115758 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000011179 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: ODC1 ornithine decarboxylase 1".

Further reading

Pegg AE (2006). "Regulation of ornithine decarboxylase.". J. Biol. Chem. 281 (21): 14529–32. PMID 16459331. doi:10.1074/jbc.R500031200.
Yoshida M, Hayashi H, Taira M, Isono K (1992). "Elevated expression of the ornithine decarboxylase gene in human esophageal cancer.". Cancer Res. 52 (23): 6671–5. PMID 1423312.
Moshier JA, Osborne DL, Skunca M, et al. (1992). "Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells.". Nucleic Acids Res. 20 (10): 2581–90. PMC 312396 . PMID 1598217. doi:10.1093/nar/20.10.2581.
Hickok NJ, Wahlfors J, Crozat A, et al. (1990). "Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene.". Gene. 93 (2): 257–63. PMID 2227439. doi:10.1016/0378-1119(90)90233-H.
Hsieh JT, Denning MF, Heidel SM, Verma AK (1990). "Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells.". Cancer Res. 50 (8): 2239–44. PMID 2317811.
Moshier JA, Gilbert JD, Skunca M, et al. (1990). "Isolation and expression of a human ornithine decarboxylase gene.". J. Biol. Chem. 265 (9): 4884–92. PMID 2318872.
Verrando P, Juhlin L, Lacour JP, Ortonne JP (1987). "Immunohistochemical localization of ornithine decarboxylase in human skin.". J. Dermatol. 14 (2): 112–7. PMID 2440930.
van Steeg H, van Oostrom CT, Martens JW, et al. (1989). "Nucleotide sequence of the human ornithine decarboxylase gene.". Nucleic Acids Res. 17 (21): 8855–6. PMC 335049 . PMID 2587220. doi:10.1093/nar/17.21.8855.
Fitzgerald MC, Flanagan MA (1990). "Characterization and sequence analysis of the human ornithine decarboxylase gene.". DNA. 8 (9): 623–34. PMID 2693021. doi:10.1089/dna.1.1989.8.623.
Alhonen-Hongisto L, Leinonen P, Sinervirta R, et al. (1987). "Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification.". Biochem. J. 242 (1): 205–10. PMC 1147684 . PMID 3036086.
Kaczmarek L, Calabretta B, Ferrari S, de Riel JK (1987). "Cell-cycle-dependent expression of human ornithine decarboxylase.". J. Cell. Physiol. 132 (3): 545–51. PMID 3308908. doi:10.1002/jcp.1041320318.
Hickok NJ, Seppänen PJ, Gunsalus GL, Jänne OA (1987). "Complete amino acid sequence of human ornithine decarboxylase deduced from complementary DNA.". DNA. 6 (3): 179–87. PMID 3595418. doi:10.1089/dna.1987.6.179.
Winqvist R, Mäkelä TP, Seppänen P, et al. (1986). "Human ornithine decarboxylase sequences map to chromosome regions 2pter----p23 and 7cen----qter but are not coamplified with the NMYC oncogene.". Cytogenet. Cell Genet. 42 (3): 133–40. PMID 3755388. doi:10.1159/000132266.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene. 150 (2): 243–50. PMID 7821789. doi:10.1016/0378-1119(94)90433-2.
Kim YJ, Pan H, Verma AK (1994). "Non-AP-1 tumor promoter 12-O-tetradecanoylphorbol-13-acetate-responsive sequences in the human ornithine decarboxylase gene.". Mol. Carcinog. 10 (3): 169–79. PMID 8043198. doi:10.1002/mc.2940100308.
Müller M, Pajunen AE, Järvinen M, et al. (1994). "Immunohistochemical demonstration of L-ornithine decarboxylase enzyme protein in different areas of the developing human brain.". Dev. Neurosci. 15 (2): 87–93. PMID 8168440. doi:10.1159/000111320.
Ichiba T, Matsufuji S, Miyazaki Y, et al. (1994). "Functional regions of ornithine decarboxylase antizyme.". Biochem. Biophys. Res. Commun. 200 (3): 1721–7. PMID 8185631. doi:10.1006/bbrc.1994.1651.
Wright PS, Cooper JR, Cross-Doersen DE, et al. (1996). "Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element.". Cell Growth Differ. 6 (9): 1097–102. PMID 8519686.
Heiskala M, Zhang J, Hayashi S, et al. (1999). "Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformation.". EMBO J. 18 (5): 1214–22. PMC 1171212 . PMID 10064588. doi:10.1093/emboj/18.5.1214.
Pomidor MM, Cimildoro R, Lazatin B, et al. (2000). "Phosphorylated human keratinocyte ornithine decarboxylase is preferentially associated with insoluble cellular proteins.". Mol. Biol. Cell. 10 (12): 4299–310. PMC 25759 . PMID 10588659. doi:10.1091/mbc.10.12.4299.
Symes AJ, Eilertsen M, Millar M, et al. (2013). "Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue". PLoS ONE. 8 (12): e84295. PMC 3874000 . PMID 24386364. doi:10.1371/journal.pone.0084295.

PDB gallery

1d7k: CRYSTAL STRUCTURE OF HUMAN ORNITHINE DECARBOXYLASE AT 2.1 ANGSTROMS RESOLUTION

7odc: CRYSTAL STRUCTURE ORNITHINE DECARBOXYLASE FROM MOUSE, TRUNCATED 37 RESIDUES FROM THE C-TERMINUS, TO 1.6 ANGSTROM RESOLUTION

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