LOC4951

OCM2

Identifiers

OCM2, OCM, LOC4951, oncomodulin 2

External IDs

HomoloGene: 130549 GeneCards: OCM2

Orthologs

Species

Human

Mouse


4951


n/a


ENSG00000135175


n/a


P0CE71


n/a

RefSeq (mRNA)


NM_006188


n/a

RefSeq (protein)


NP_006179


n/a

Location (UCSC)

Chr 7: 97.98 – 97.99 Mb

n/a

PubMed search

^[1]

n/a

View/Edit Human

Oncomodulin, also known as OCM, is a human gene.^[2]

Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors.^[2]

References

Further reading

Pauls TL, Cox JA, Berchtold MW (1996). "The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings.". Biochim. Biophys. Acta. 1306 (1): 39–54. PMID 8611623. doi:10.1016/0167-4781(95)00221-9.
Belkacemi L, Simoneau L, Lafond J (2003). "Calcium-binding proteins: distribution and implication in mammalian placenta.". Endocrine. 19 (1): 57–64. PMID 12583602. doi:10.1385/ENDO:19:1:57.
Ritzler JM, Sawhney R, Geurts van Kessel AH, et al. (1992). "The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome.". Genomics. 12 (3): 567–72. PMID 1559707. doi:10.1016/0888-7543(92)90449-3.
Palmer EJ, MacManus JP, Mutus B (1990). "Inhibition of glutathione reductase by oncomodulin.". Arch. Biochem. Biophys. 277 (1): 149–54. PMID 2306116. doi:10.1016/0003-9861(90)90563-E.
Mutus B, Palmer EJ, MacManus JP (1988). "Disulfide-linked dimer of oncomodulin: comparison to calmodulin.". Biochemistry. 27 (15): 5615–22. PMID 3179268. doi:10.1021/bi00415a033.
Gillen MF, Banville D, Rutledge RG, et al. (1987). "A complete complementary DNA for the oncodevelopmental calcium-binding protein, oncomodulin.". J. Biol. Chem. 262 (11): 5308–12. PMID 3558395.
MacManus JP, Brewer LM, Whitfield JF (1985). "The widely-distributed tumour protein, oncomodulin, is a normal constituent of human and rodent placentas.". Cancer Lett. 27 (2): 145–51. PMID 4005827. doi:10.1016/0304-3835(85)90103-X.
Blum JK, Berchtold MW (1994). "Calmodulin-like effect of oncomodulin on cell proliferation.". J. Cell. Physiol. 160 (3): 455–62. PMID 8077283. doi:10.1002/jcp.1041600308.
Föhr UG, Weber BR, Müntener M, et al. (1993). "Human alpha and beta parvalbumins. Structure and tissue-specific expression.". Eur. J. Biochem. 215 (3): 719–27. PMID 8354278. doi:10.1111/j.1432-1033.1993.tb18084.x.
Sakaguchi N, Henzl MT, Thalmann I, et al. (2000). "Oncomodulin is expressed exclusively by outer hair cells in the organ of Corti.". J. Histochem. Cytochem. 46 (1): 29–40. PMID 9405492. doi:10.1177/002215549804600105.
"Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074. doi:10.1101/gr.8.11.1097.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. PMID 11329013. doi:10.1038/88107.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Babini E, Bertini I, Capozzi F, et al. (2005). "Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs". Biochemistry. 43 (51): 16076–85. PMID 15610002. doi:10.1021/bi048388o.

PDB gallery

1omd: STRUCTURE OF ONCOMODULIN REFINED AT 1.85 ANGSTROMS RESOLUTION. AN EXAMPLE OF EXTENSIVE MOLECULAR AGGREGATION VIA CA2+

1rro: REFINEMENT OF RECOMBINANT ONCOMODULIN AT 1.30 ANGSTROMS RESOLUTION

1ttx: Solution structure of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.