OAZ2

OAZ2
Identifiers
Aliases	OAZ2, AZ2, ornithine decarboxylase antizyme 2
External IDs	MGI: 109492 HomoloGene: 31094 GeneCards: OAZ2
Gene location (Human) Chr. Chromosome 15 (human)[1] Band No data available Start 64,687,573 bp[1] End 64,703,281 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band No data available Start 65,668,001 bp[2] End 65,690,300 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ornithine decarboxylase inhibitor activity • protein binding Cellular component • cytosol • nucleus • cytoplasm Biological process • positive regulation of intracellular protein transport • polyamine biosynthetic process • polyamine metabolic process • negative regulation of polyamine transmembrane transport • negative regulation of catalytic activity • regulation of cellular amino acid metabolic process • positive regulation of protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4947	18247
Ensembl	ENSG00000180304	ENSMUSG00000040652
UniProt	O95190	O08608
RefSeq (mRNA)	NM_002537 NM_001301302	NM_001301307 NM_010952
RefSeq (protein)	NP_001288231 NP_002528	NP_001288236 NP_035082
Location (UCSC)	Chr 15: 64.69 – 64.7 Mb	Chr 15: 65.67 – 65.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Ornithine decarboxylase antizyme 2 is an enzyme that in humans is encoded by the OAZ2 gene.^[5][6][7]

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation.^[7]

References

Further reading