Nur (biology)
Nur (nuclear receptor subfamily 4) is a family of orphan nuclear receptors which act as transcription factors in neuron development and maintenance. Recently, members of the NR4A family have been implicated in the control of skeletal muscle metabolism.[1][2]
Three members have been identified in humans:[3][4]
- nerve Growth factor IB (Nur77, or NR4A1),
- nuclear receptor related 1 protein (Nurr1, or NR4A2), and
- neuron-derived orphan receptor 1 (Nor-1, or NR4A3).
References
- ↑ Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology. 147 (11): 5217–27. PMID 16901967. doi:10.1210/en.2006-0447.
- ↑ Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology. 149 (6): 2853–65. PMID 18325999. doi:10.1210/en.2007-1202.
- ↑ Maxwell MA, Muscat GE (2006). "The NR4A subgroup: immediate early response genes with pleiotropic physiological roles". Nucl Recept Signal. 4: e002. PMC 1402209
. PMID 16604165. doi:10.1621/nrs.04002. - ↑ Maheux J, Ethier I, Rouillard C, Lévesque D (2005). "Induction patterns of transcription factors of the nur family (nurr1, nur77, and nor-1) by typical and atypical antipsychotics in the mouse brain: implication for their mechanism of action". J. Pharmacol. Exp. Ther. 313 (1): 460–73. PMID 15615863. doi:10.1124/jpet.104.080184.
This article is issued from
Wikipedia.
The text is licensed under Creative Commons - Attribution - Sharealike.
Additional terms may apply for the media files.