NrrF RNA

NrrF RNA

Predicted secondary structure of NrrF RNA
Identifiers
Symbol NrrF
Rfam RF01416
Other data
RNA type gene, antisense RNA
Domain(s) Neisseria
SO {{{SO}}}

NrrF is a non-coding RNA which is regulated by the Ferric uptake regulator (Fur) protein in bacteria. This non-coding RNA was identified in Neisseria meningitidis and is involved in iron regulation of the succinate dehydrogenase genes sdhA and sdhC.[1][2] NrrF acts as an antisense RNA and is complementary to the junction between the second and third genes of the sdh operon (sdhD and sdhA). Secondary structure predictions have indicated that this interaction occurs in a single stranded loop region of the NrrF RNA. Under low iron concentration NrrF is present at a high concentration and forms a duplex with the transcript in Hfq dependent manner. The RNA chaperone Hfq acts to enhance binding of NrrF or stabilizes the NrrF/sdh transcript duplex. Binding of NrrF results in down regulation of the sdhCDAB mRNA transcript results in a Fur-dependent positive regulation of succinate dehydrogenase.

NrrF appears to be restricted to the Neisseria species and no homologues have yet been identified in other species.

See also

References

  1. ↑ Mellin, J. R.; Goswami, S.; Grogan, S.; Tjaden, B.; Genco, C. A. (May 2007). "A novel fur- and iron-regulated small RNA, NrrF, is required for indirect fur-mediated regulation of the sdhA and sdhC genes in Neisseria meningitidis". J. Bacteriol. 189 (10): 3686–94. PMC 1913314 Freely accessible. PMID 17351036. doi:10.1128/JB.01890-06.
  2. ↑ Metruccio, M. M. E.; Fantappiè, L.; Serruto, D.; Muzzi, A.; Roncarati, D.; Donati, C.; Scarlato, V.; Delany, I. (February 2009). "The Hfq-dependent small noncoding RNA NrrF directly mediates Fur-dependent positive regulation of succinate dehydrogenase in Neisseria meningitidis". J. Bacteriol. 191 (4): 1330–42. PMC 2631994 Freely accessible. PMID 19060140. doi:10.1128/JB.00849-08.

Further reading


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