Phorbol-12-myristate-13-acetate-induced protein 1

PMAIP1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesPMAIP1, APR, NOXA, phorbol-12-myristate-13-acetate-induced protein 1
External IDsOMIM: 604959 HomoloGene: 88883 GeneCards: PMAIP1
Gene location (Human)
Chr.Chromosome 18 (human)[1]
BandNo data availableStart59,899,948 bp[1]
End59,904,306 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5366

n/a

Ensembl

ENSG00000141682

n/a

UniProt

Q13794

n/a

RefSeq (mRNA)

NM_021127

n/a

RefSeq (protein)

NP_066950

n/a

Location (UCSC)Chr 18: 59.9 – 59.9 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.[3][4][5]

Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family.[6] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.

Interactions

Noxa has been shown to interact with:

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000141682 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K (October 1990). "Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line". J Virol. 64 (10): 4632–9. PMC 247947 Freely accessible. PMID 2398525.
  4. ↑ Jansson AK, Emterling AM, Arbman G, Sun XF (July 2003). "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene. 22 (30): 4675–8. PMID 12879012. doi:10.1038/sj.onc.1206655.
  5. ↑ "Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1".
  6. ↑ Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–1058. PMID 10807576. doi:10.1126/science.288.5468.1053.
  7. 1 2 3 Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell. 17 (3): 393–403. PMID 15694340. doi:10.1016/j.molcel.2004.12.030.
  8. 1 2 Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–8. PMID 10807576. doi:10.1126/science.288.5468.1053.
  9. ↑ Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC (June 2005). "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins". Genes Dev. 19 (11): 1294–305. PMC 1142553 Freely accessible. PMID 15901672. doi:10.1101/gad.1304105.

Further reading

  • Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.". Science. 288 (5468): 1053–8. PMID 10807576. doi:10.1126/science.288.5468.1053. 
  • Seo YW, Shin JN, Ko KH, Cha JH, Park JY, Lee BR, Yun CW, Kim YM, Seol DW, Kim DW, Yin XM, Kim TH (2004). "The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death.". J. Biol. Chem. 278 (48): 48292–9. PMID 14500711. doi:10.1074/jbc.M308785200. 
  • Kim JY, Ahn HJ, Ryu JH, Suk K, Park JH (2004). "BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha.". J. Exp. Med. 199 (1): 113–24. PMC 1887730 Freely accessible. PMID 14699081. doi:10.1084/jem.20030613. 
  • Yakovlev AG, Di Giovanni S, Wang G, Liu W, Stoica B, Faden AI (2004). "BOK and NOXA are essential mediators of p53-dependent apoptosis.". J. Biol. Chem. 279 (27): 28367–74. PMID 15102863. doi:10.1074/jbc.M313526200. 
  • Qin JZ, Stennett L, Bacon P, Bodner B, Hendrix MJ, Seftor RE, Seftor EA, Margaryan NV, Pollock PM, Curtis A, Trent JM, Bennett F, Miele L, Nickoloff BJ (2005). "p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas.". Mol. Cancer Ther. 3 (8): 895–902. PMID 15299072. 
  • Flinterman M, Guelen L, Ezzati-Nik S, Killick R, Melino G, Tominaga K, Mymryk JS, Gäken J, Tavassoli M (2005). "E1A activates transcription of p73 and Noxa to induce apoptosis.". J. Biol. Chem. 280 (7): 5945–59. PMID 15572378. doi:10.1074/jbc.M406661200. 
  • Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.". Mol. Cell. 17 (3): 393–403. PMID 15694340. doi:10.1016/j.molcel.2004.12.030. 
  • Sun Y, Leaman DW (2005). "Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection.". J. Biol. Chem. 280 (16): 15561–8. PMID 15705586. doi:10.1074/jbc.M412630200. 
  • Ceballos E, Muñoz-Alonso MJ, Berwanger B, Acosta JC, Hernández R, Krause M, Hartmann O, Eilers M, León J (2005). "Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes.". Oncogene. 24 (28): 4559–71. PMID 15856024. doi:10.1038/sj.onc.1208652. 
  • Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC (2005). "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.". Genes Dev. 19 (11): 1294–305. PMC 1142553 Freely accessible. PMID 15901672. doi:10.1101/gad.1304105. 
  • Alves NL, Derks IA, Berk E, Spijker R, van Lier RA, Eldering E (2006). "The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells.". Immunity. 24 (6): 703–16. PMID 16782027. doi:10.1016/j.immuni.2006.03.018. 
  • Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ (2007). "FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells.". Cell Death Differ. 14 (3): 534–47. PMID 16888645. doi:10.1038/sj.cdd.4402017. 
  • Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY (2006). "Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa.". J. Biol. Chem. 281 (42): 31440–7. PMID 16928686. doi:10.1074/jbc.M604356200. 
  • Smit LA, Hallaert DY, Spijker R, de Goeij B, Jaspers A, Kater AP, van Oers MH, van Noesel CJ, Eldering E (2007). "Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity.". Blood. 109 (4): 1660–8. PMID 17038534. doi:10.1182/blood-2006-05-021683. 
  • Armstrong JL, Veal GJ, Redfern CP, Lovat PE (2007). "Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours.". Apoptosis. 12 (3): 613–22. PMID 17216584. doi:10.1007/s10495-006-0020-1. 
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