Intracellular calcium-sensing proteins

Intracellular calcium-sensing proteins are proteins that act in the second messenger system.

Examples include:

References

↑ Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton (Hoboken). 70 (11): 775–95. PMID 24155256. doi:10.1002/cm.21149.

MAP

Calcium

cAMP:	Heterotrimeric G protein Gs/Gi Adenylate cyclase cAMP 3',5'-cyclic-AMP phosphodiesterase Protein kinase A
cGMP:	Transducin Gustducin Guanylate cyclase cGMP 3',5'-cyclic-GMP phosphodiesterase Protein kinase G
G alpha subunit G_α GNAO1 GNAI1 GNAI2 GNAI3 GNAT1 GNAT2 GNAT3 GNAZ GNAS GNAL GNAQ GNA11 GNA12 GNA13 GNA14 GNA15/GNA16
G beta-gamma complex G_β GNB1 GNB2 GNB3 GNB4 GNB5 G_γ GNGT1 GNGT2 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG10 GNG11 GNG12 GNG13 BSCL2
G protein-coupled receptor kinase AMP-activated protein kinase

Cyclin

Lipid

Serine/threonine:	Casein kinase 1 2 eIF-2 kinase EIF2AK3 Glycogen synthase kinase GSK1 GSK2 GSK-3 GSK3A GSK3B IκB kinase CHUK IKK2 IKBKG Interleukin-1 receptor-associated kinase IRAK1 IRAK2 IRAK3 IRAK4 Lim kinase LIMK1 LIMK2 p21-activated kinases PAK1 PAK2 PAK3 PAK4 Rho-associated protein kinase ROCK1 ROCK2 Ribosomal s6 kinase RPS6KA1
Tyrosine:	ZAP70 Focal adhesion protein-tyrosine kinase PTK2 PTK2B BTK
both	Dual-specificity kinase

Serine/threonine:	Protein phosphatase 2
Tyrosine:	protein tyrosine phosphatase: Receptor-like protein tyrosine phosphatase Sh2 domain-containing protein tyrosine phosphatase
both:	Dual-specificity phosphatase

Other

see also deficiencies of intracellular signaling peptides and proteins

Ion pumps	SERCA Sodium-calcium exchanger
Cell membrane calcium channels	VDCC TRP NMDA receptor AMPA receptor 5-HT3 receptor P2X purinoreceptor
Adhesion molecules	Cadherin
Other	Calcium-sensing receptor

Second messengers	IP3 NAADP cADPR
Store gates (ligand-gated calcium channel)	IP3 receptor CICR Ryanodine receptor
Molecular switches, and kinases	Troponin C Calmodulin CaM kinases PKC NCS
Chelators and calcium sensors	Calbindin S100 pervalbumin Calretinin Calsequestrin Sarcalumenin Phospholamban Synaptotagmins
Proteases	Calpain
Cytoskeleton remodeling proteins	Gelsolin
Chaperones	Calreticulin Calnexin
Other	Vitamin D

Extracellular ligands

Intracellular calcium-sensing proteins	Calmodulin Calnexin Calreticulin Gelsolin neuronal Hippocalcin Neurocalcin Recoverin
Membrane protein	Annexin A1 A2 A5 Fibulin FBLN1 FBLN2 FBLN5 Vitamin D-dependent calcium-binding protein/Calbindin Calexcitin Calsequestrin Osteocalcin Osteonectin S-100 Synaptotagmin
Cytoskeleton	Troponin C
Extracellular matrix	Matrix gla protein

Ion pumps	SERCA Sodium-calcium exchanger
Cell membrane calcium channels	VDCC TRP NMDA receptor AMPA receptor 5-HT3 receptor P2X purinoreceptor
Adhesion molecules	Cadherin
Other	Calcium-sensing receptor

Second messengers	IP3 NAADP cADPR
Store gates (ligand-gated calcium channel)	IP3 receptor CICR Ryanodine receptor
Molecular switches, and kinases	Troponin C Calmodulin CaM kinases PKC NCS
Chelators and calcium sensors	Calbindin S100 pervalbumin Calretinin Calsequestrin Sarcalumenin Phospholamban Synaptotagmins
Proteases	Calpain
Cytoskeleton remodeling proteins	Gelsolin
Chaperones	Calreticulin Calnexin
Other	Vitamin D

Extracellular ligands

Intracellular calcium-sensing proteins	Calmodulin Calnexin Calreticulin Gelsolin neuronal Hippocalcin Neurocalcin Recoverin
Membrane protein	Annexin A1 A2 A5 Fibulin FBLN1 FBLN2 FBLN5 Vitamin D-dependent calcium-binding protein/Calbindin Calexcitin Calsequestrin Osteocalcin Osteonectin S-100 Synaptotagmin
Cytoskeleton	Troponin C
Extracellular matrix	Matrix gla protein

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