CSPG4
Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.[3][4][5]
CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.[5]
See also
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA (Oct 1996). "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan". Proc Natl Acad Sci U S A. 93 (18): 9710–5. PMC 38494
. PMID 8790396. doi:10.1073/pnas.93.18.9710. - ↑ Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S (May 2006). "Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells". Oncogene. 25 (20): 2873–84. PMID 16407841. doi:10.1038/sj.onc.1209319.
- 1 2 "Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4".
Further reading
- Kirschfink M, Blase L, Engelmann S, Schwartz-Albiez R (1997). "Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex formation of C1.". J. Immunol. 158 (3): 1324–31. PMID 9013976.
- Iida J, Meijne AM, Oegema TR, et al. (1998). "A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion.". J. Biol. Chem. 273 (10): 5955–62. PMID 9488735. doi:10.1074/jbc.273.10.5955.
- Eisenmann KM, McCarthy JB, Simpson MA, et al. (2000). "Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.". Nat. Cell Biol. 1 (8): 507–13. PMID 10587647. doi:10.1038/70302.
- Barritt DS, Pearn MT, Zisch AH, et al. (2000). "The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2.". J. Cell. Biochem. 79 (2): 213–24. PMC 3501957 . PMID 10967549. doi:10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G.
- Iida J, Pei D, Kang T, et al. (2001). "Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen.". J. Biol. Chem. 276 (22): 18786–94. PMID 11278606. doi:10.1074/jbc.M010053200.
- Staub E, Hinzmann B, Rosenthal A (2002). "A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family.". FEBS Lett. 527 (1-3): 114–8. PMID 12220645. doi:10.1016/S0014-5793(02)03195-2.
- Stegmüller J, Werner H, Nave KA, Trotter J (2003). "The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling.". J. Biol. Chem. 278 (6): 3590–8. PMID 12458226. doi:10.1074/jbc.M210010200.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Legg J, Jensen UB, Broad S, et al. (2004). "Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis.". Development. 130 (24): 6049–63. PMID 14573520. doi:10.1242/dev.00837.
- Ghali L, Wong ST, Tidman N, et al. (2004). "Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein.". J. Invest. Dermatol. 122 (2): 433–42. PMID 15009727. doi:10.1046/j.0022-202X.2004.22207.x.
- Fukushi J, Makagiansar IT, Stallcup WB (2005). "NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.". Mol. Biol. Cell. 15 (8): 3580–90. PMC 491820 . PMID 15181153. doi:10.1091/mbc.E04-03-0236.
- Yang J, Price MA, Neudauer CL, et al. (2004). "Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms.". J. Cell Biol. 165 (6): 881–91. PMC 2172406 . PMID 15210734. doi:10.1083/jcb.200403174.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. PMC 515316 . PMID 15342556. doi:10.1101/gr.2435604.
- Makagiansar IT, Williams S, Dahlin-Huppe K, et al. (2005). "Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility.". J. Biol. Chem. 279 (53): 55262–70. PMID 15504744. doi:10.1074/jbc.M411045200.
- Petrini S, Tessa A, Stallcup WB, et al. (2006). "Altered expression of the MCSP/NG2 chondroitin sulfate proteoglycan in collagen VI deficiency.". Mol. Cell. Neurosci. 30 (3): 408–17. PMID 16169245. doi:10.1016/j.mcn.2005.08.005.
- Brekke C, Lundervold A, Enger PØ, et al. (2006). "NG2 expression regulates vascular morphology and function in human brain tumours.". NeuroImage. 29 (3): 965–76. PMID 16253523. doi:10.1016/j.neuroimage.2005.08.026.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. PMC 1850943 . PMID 16335952. doi:10.1021/pr0502065.
External links
- Human CSPG4 genome location and CSPG4 gene details page in the UCSC Genome Browser.
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