NETO1
Neuropilin (NRP) and tolloid (TLL)-like 1 is a protein that in humans is encoded by the NETO1 gene.[5]
Function
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
References
Further reading
- Ng D, Pitcher GM, Szilard RK, Sertié A, Kanisek M, Clapcote SJ, Lipina T, Kalia LV, Joo D, McKerlie C, Cortez M, Roder JC, Salter MW, McInnes RR (February 2009). "Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning". PLoS Biology. 7 (2): e41. PMC 2652390
. PMID 19243221. doi:10.1371/journal.pbio.1000041. - Banno M, Koide T, Aleksic B, Yamada K, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Ikeda M, Inada T, Yoshikawa T, Iwata N, Ozaki N (2011). "A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population". PloS One. 6 (12): e28929. PMC 3243668 . PMID 22205981. doi:10.1371/journal.pone.0028929.
- Stöhr H, Berger C, Fröhlich S, Weber BH (March 2002). "A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain". Gene. 286 (2): 223–31. PMID 11943477. doi:10.1016/s0378-1119(02)00438-9.
- Benjamin DJ, Cesarini D, van der Loos MJ, Dawes CT, Koellinger PD, Magnusson PK, Chabris CF, Conley D, Laibson D, Johannesson M, Visscher PM (May 2012). "The genetic architecture of economic and political preferences". Proceedings of the National Academy of Sciences of the United States of America. 109 (21): 8026–31. PMC 3361436 . PMID 22566634. doi:10.1073/pnas.1120666109.
- O'Donnell L, Soileau B, Heard P, Carter E, Sebold C, Gelfond J, Hale DE, Cody JD (August 2010). "Genetic determinants of autism in individuals with deletions of 18q". Human Genetics. 128 (2): 155–64. PMID 20499253. doi:10.1007/s00439-010-0839-y.
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