Neticonazole

Neticonazole
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	none
Identifiers
IUPAC name 1-{(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole
PubChem CID	5282433
ChemSpider	4445587^N
UNII	KVL61ZF9UO
Chemical and physical data
Formula	C₁₇H₂₂N₂OS
Molar mass	302.43 g/mol
3D model (JSmol)	Interactive image
SMILES CCCCCOc1ccccc1/C(=C\SC)/n2ccnc2
InChI InChI=1S/C17H22N2OS/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3/b16-13+^N Key:VWOIKFDZQQLJBJ-DTQAZKPQSA-N^N
^NY (what is this?) (verify)

Neticonazole (INN) is an imidazole antifungal for the treatment of fungal skin infections.^[1]^[2]

Neticonazole is only approved for use in Japan. It is sold as a topical ointment under the tradename Atolant.

References

↑ Nimura K, Niwano Y, Ishiduka S, Fukumoto R (August 2001). "Comparison of in vitro antifungal activities of topical antimycotics launched in 1990s in Japan". Int. J. Antimicrob. Agents. 18 (2): 173–8. PMID 11516941. doi:10.1016/S0924-8579(01)00365-X.
↑ Tsuboi R, Matsumoto T, Ogawa H (May 1996). "Hyperkeratotic chronic tinea pedis treated with neticonazole cream. Neticonazole Study Group". Int. J. Dermatol. 35 (5): 371–3. PMID 8734665. doi:10.1111/j.1365-4362.1996.tb03644.x.

Wall/
membrane

Ergosterol
inhibitors

Imidazoles	Topical: bifonazole^‡ butoconazole chlormidazole^‡ clotrimazole^# croconazole^‡ eberconazole econazole fenticonazole^‡ flutrimazole isoconazole^‡ ketoconazole luliconazole miconazole^# neticonazole^‡ omoconazole^‡ oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole
Triazoles	Topical: efinaconazole fluconazole^# fosfluconazole terconazole Systemic: fluconazole^# hexaconazole^‡ isavuconazole itraconazole posaconazole voriconazole Unknown: albaconazole^‡ ravuconazole^†
Thiazoles	Topical: abafungin^‡

Allylamines	Topical: naftifine terbinafine Systemic: terbinafine
Benzylamines	Topical: butenafine

Others

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	flucytosine^#
Mitotic inhibitors	griseofulvin^#
Aminoacyl tRNA synthetase inhibitors	tavaborole

Others

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