Epoetin beta
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| Trade names | NeoRecormon, Betapoietin, others[1] |
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| Routes of administration | Intravenous, subcutaneous |
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Epoetin beta (rINN) /ɛˈpoʊ.ɪtɪn/ is a synthetic, recombinant[2] form of erythropoietin, a protein that promotes the production of red blood cells. It is an erythropoiesis-stimulating agent (ESA) that is used to treat anemia, commonly associated with chronic renal failure and cancer chemotherapy.
Epoetin beta is marketed under the trade name NeoRecormon, among others.[3]
Chemistry
Epoetin beta is a recombinant form of human erythropoietin which is produced in Chinese hamster ovary cells. It has the same protein sequence as natural human erythropoietin, being composed of 165 amino acids with about 30 KDa molecular weight.[4]
History
Erythropoietin (EPO) is a hormone produced in the kidneys. The existence of this hormone has been known since 1906, when scientists first started isolating it, and since the 1980s, a recombinant version of the hormone has been available for use in medical treatment.
See also
References
- ↑ Centers for Medicare and Medicaid Services: Erythrocyte Stimulating Agents. Accessed 15 February 2017.
- ↑ Dunn CJ, Markham A (1996). "Epoetin beta. A review of its pharmacological properties and clinical use in the management of anaemia associated with chronic renal failure". Drugs. 51 (2): 299–318. PMID 8808169. doi:10.2165/00003495-199651020-00008.
- ↑ Amgen - Products. URL: http://www.amgen.com/patients/prca.html. Accessed 21 October 2007.
- ↑ Medsafe: NeoRecormon Datasheet
External links
- Jenkins, John K. (2007-06-26). "Congressional Testimony: Erythropoiesis-Stimulating Agents (ESA)". News & Events. FDA. Retrieved 2010-02-25.