NRD1
Nardilysin is a protein that in humans is encoded by the NRD1 gene.[5][6][7]
Interactions
NRD1 has been shown to interact with Heparin-binding EGF-like growth factor.[8]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000078618 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053510 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P (May 1998). "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family". Biochem J. 327 (3): 773–9. PMC 1218856
. PMID 9581555. - ↑ Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R (Apr 1998). "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues". Genomics. 47 (2): 238–45. PMID 9479496. doi:10.1006/geno.1997.5078.
- ↑ "Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)".
- ↑ Nishi, E; Prat A; Hospital V; Elenius K; Klagsbrun M (Jul 2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. England. 20 (13): 3342–50. ISSN 0261-4189. PMC 125525 . PMID 11432822. doi:10.1093/emboj/20.13.3342.
Further reading
- Seidah NG, Prat A (2003). "Precursor convertases in the secretory pathway, cytosol and extracellular milieu.". Essays Biochem. 38: 79–94. PMID 12463163.
- Hospital V, Prat A (2005). "Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation.". Protein Pept. Lett. 11 (5): 501–8. PMID 15544571. doi:10.2174/0929866043406508.
- Winter AG, Pierotti AR (2001). "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines.". Biochem. J. 351 (3): 755–64. PMC 1221416 . PMID 11042131. doi:10.1042/0264-6021:3510755.
- Nishi E, Prat A, Hospital V, et al. (2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration.". EMBO J. 20 (13): 3342–50. PMC 125525 . PMID 11432822. doi:10.1093/emboj/20.13.3342.
- Ma Z, Csuhai E, Chow KM, Hersh LB (2001). "Expression of the acidic stretch of nardilysin as a functional binding domain.". Biochemistry. 40 (31): 9447–52. PMID 11478915. doi:10.1021/bi010538x.
- Hospital V, Nishi E, Klagsbrun M, et al. (2003). "The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF).". Biochem. J. 367 (Pt 1): 229–38. PMC 1222870 . PMID 12095415. doi:10.1042/BJ20020822.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Chow KM, Oakley O, Goodman J, et al. (2003). "Nardilysin cleaves peptides at monobasic sites.". Biochemistry. 42 (7): 2239–44. PMID 12590613. doi:10.1021/bi027178d.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.
- Nishi E, Hiraoka Y, Yoshida K, et al. (2006). "Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme.". J. Biol. Chem. 281 (41): 31164–72. PMID 16923819. doi:10.1074/jbc.M601316200.
- Bernstein HG, Stricker R, Dobrowolny H, et al. (2007). "Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons.". Neuroscience. 146 (4): 1513–23. PMID 17442499. doi:10.1016/j.neuroscience.2007.02.057.
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