Neuropeptide FF receptor 2

NPFFR2

Identifiers

NPFFR2, GPR74, HLWAR77, NPFF2, NPGPR, neuropeptide FF receptor 2

External IDs

MGI: 1860130 HomoloGene: 56982 GeneCards: NPFFR2

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	No data available	Start	72,031,804 bp^[1]
Band	No data available	End	72,148,067 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	No data available	Start	89,527,429 bp^[2]
Band	No data available	End	89,583,740 bp^[2]

Gene ontology
Molecular function	• opioid receptor binding • peptide binding • G-protein coupled receptor activity • signal transducer activity • neuropeptide receptor activity
Cellular component	• integral component of membrane • plasma membrane • integral component of plasma membrane • membrane • actin cytoskeleton
Biological process	• G-protein coupled receptor signaling pathway • detection of abiotic stimulus • cellular response to hormone stimulus • regulation of MAPK cascade • regulation of adenylate cyclase activity • regulation of cAMP-dependent protein kinase activity • signal transduction • response to peptide • neuropeptide signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10886


104443

Ensembl


ENSG00000056291


ENSMUSG00000035528

UniProt


Q9Y5X5


Q924H0

RefSeq (mRNA)


NM_001144756 NM_004885 NM_053036


NM_133192

RefSeq (protein)


NP_001138228 NP_004876 NP_444264


NP_573455

Location (UCSC)

Chr 4: 72.03 – 72.15 Mb

Chr 4: 89.53 – 89.58 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000056291 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035528 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: NPFFR2 neuropeptide FF receptor 2".

External links

"Neuropeptide FF Receptors: NPFF2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Cikos S, Gregor P, Koppel J (1999). "Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta.". Biochem. Biophys. Res. Commun. 256 (2): 352–6. PMID 10079187. doi:10.1006/bbrc.1999.0332.
Parker RM, Copeland NG, Eyre HJ, et al. (2000). "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family.". Brain Res. Mol. Brain Res. 77 (2): 199–208. PMID 10837915. doi:10.1016/S0169-328X(00)00052-8.
Elshourbagy NA, Ames RS, Fitzgerald LR, et al. (2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.". J. Biol. Chem. 275 (34): 25965–71. PMID 10851242. doi:10.1074/jbc.M004515200.
Bonini JA, Jones KA, Adham N, et al. (2001). "Identification and characterization of two G protein-coupled receptors for neuropeptide FF.". J. Biol. Chem. 275 (50): 39324–31. PMID 11024015. doi:10.1074/jbc.M004385200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Laemmle B, Schindler M, Beilmann M, et al. (2003). "Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus.". Regul. Pept. 111 (1–3): 21–9. PMID 12609745. doi:10.1016/S0167-0115(02)00220-3.
Engström M, Wurster S, Savola JM, Panula P (2004). "Functional properties of Pfr(Tic)amide and BIBP3226 at human neuropeptide FF2 receptors". Peptides. 24 (12): 1947–54. PMID 15127947. doi:10.1016/j.peptides.2003.10.009.
Mollereau C, Mazarguil H, Zajac JM, Roumy M (2005). "Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells". Mol. Pharmacol. 67 (3): 965–75. PMID 15608144. doi:10.1124/mol.104.004614.
Ankö ML, Panula P (2006). "Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line". J. Neurochem. 96 (2): 573–84. PMID 16336216. doi:10.1111/j.1471-4159.2005.03581.x.
Ankö ML, Ostergård M, Lintunen M, Panula P (2007). "Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression". FEBS Lett. 580 (30): 6955–60. PMID 17157836. doi:10.1016/j.febslet.2006.11.063.
Dahlman I, Dicker A, Jiao H, et al. (2007). "A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis". Am. J. Hum. Genet. 80 (6): 1115–24. PMC 1867099 . PMID 17503329. doi:10.1086/518445.

Cell surface receptor: G protein–coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a)
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin & Zeta, but not Sigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRG (1 2 3 4 5 6 7)
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor)
Other	Calcium-sensing receptor GABAB (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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Neuropeptide FF receptor 2

See also

References

External links

Further reading