NLRP9

Identifiers

NLRP9, CLR19.1, NALP9, NOD6, PAN12, NLR family, pyrin domain containing 9, NLR family pyrin domain containing 9

External IDs

Gene ontology
Molecular function	• ATP binding • nucleotide binding • protein binding
Cellular component	• cytoplasm • inflammasome complex
Biological process	• positive regulation of interleukin-18 production • innate immune response • defense response to virus • pyroptosis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


338321


243874


ENSG00000185792


ENSMUSG00000060508


Q7RTR0


Q66X22

RefSeq (mRNA)


NM_176820


NM_194058

RefSeq (protein)


NP_789790


NP_918947

Location (UCSC)

PubMed search

^[3]

^[4]

NLRP9, short for NOD-like receptor family pyrin domain containing 9, is an intracellular protein that is expressed in the ovaries, testes, oocytes, and preimplantation embryos of mammals that is likely involved in reproductive processes.^[5]^[6]^[7] It is also known as NALP9, NOD6, PAN12, and CLR19.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185792 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060508 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Dalbiès-Tran R, Papillier P, Pennetier S, Uzbekova S, Monget P (August 2005). "Bovine mater-like NALP9 is an oocyte marker gene". Mol. Reprod. Dev. 71 (4): 414–21. PMID 15892040. doi:10.1002/mrd.20298.
↑ Ponsuksili S, Brunner RM, Goldammer T, et al. (March 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". Biol. Reprod. 74 (3): 577–84. PMID 16339045. doi:10.1095/biolreprod.105.045096.
↑ Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". BMC Evol. Biol. 9: 202. PMC 2735741 . PMID 19682372. doi:10.1186/1471-2148-9-202.

Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis.". Nat. Rev. Immunol. 3 (5): 371–82. PMID 12766759. doi:10.1038/nri1086.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation.". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. PMID 12563287. doi:10.1038/nrm1019.

NOD-like receptor family
CARD domain containing	NOD1/NLRC1 NOD2/NLRC2 NLRC3 NLRC4 NLRC5
Pyrin domain containing	NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6 NLRP7 NLRP8 NLRP9 NLRP10 NLRP11 NLRP12 NLRP13 NLRP14
Apoptosis inhibitory protein	NAIP
Family member X1	NLRX1

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