NLRP5

NLRP5
Identifiers
AliasesNLRP5, CLR19.8, MATER, NALP5, PAN11, PYPAF8, NLR family, pyrin domain containing 5, NLR family pyrin domain containing 5
External IDsMGI: 1345193 HomoloGene: 65105 GeneCards: NLRP5
Gene location (Human)
Chr.Chromosome 19 (human)[1]
BandNo data availableStart55,999,726 bp[1]
End56,061,813 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

126206

23968

Ensembl

ENSG00000171487

ENSMUSG00000015721

UniProt

P59047

Q9R1M5

RefSeq (mRNA)

NM_153447

NM_001039143
NM_011860
NM_001305857

RefSeq (protein)

NP_703148

NP_001034232
NP_001292786
NP_035990

Location (UCSC)Chr 19: 56 – 56.06 MbChr 19: 23.39 – 23.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis.[5][6] NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals.

In humans, the NLRP5 protein is encoded by the NLRP5 gene.[7][8][9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171487 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015721 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Wu X (February 2009). "Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta)". Hum. Reprod. 24 (2): 415–24. PMID 19054779. doi:10.1093/humrep/den403.
  6. ↑ Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P (February 2010). "Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells". J. Reprod. Dev. 56 (1): 41–8. PMID 19815987. doi:10.1262/jrd.09-098a.
  7. ↑ "Entrez Gene: NLR family".
  8. ↑ Tong ZB, Bondy CA, Zhou J, Nelson LM (April 2002). "A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development". Hum. Reprod. 17 (4): 903–11. PMID 11925379. doi:10.1093/humrep/17.4.903.
  9. ↑ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. PMID 12563287. doi:10.1038/nrm1019.

Further reading

  • Maraldi T, Riccio M, Sena P, et al. (2009). "MATER protein as substrate of PKCepsilon in human cumulus cells.". Mol. Hum. Reprod. 15 (8): 499–506. PMID 19542546. doi:10.1093/molehr/gap048. 
  • Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.". Cancer Res. 68 (24): 10178–86. PMID 19074885. doi:10.1158/0008-5472.CAN-08-2221. 
  • Alimohammadi M, Björklund P, Hallgren A, et al. (2008). "Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen.". N. Engl. J. Med. 358 (10): 1018–28. PMID 18322283. doi:10.1056/NEJMoa0706487. 
  • Sena P, Riccio M, Marzona L, et al. (2009). "Human MATER localization in specific cell domains of oocytes and follicular cells.". Reprod. Biomed. Online. 18 (2): 226–34. PMID 19192343. doi:10.1016/s1472-6483(10)60260-x. 


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