NKRF (gene)

NKRF

Identifiers

NKRF, ITBA4, NRF, NFKB repressing factor

External IDs

MGI: 1924536 HomoloGene: 84816 GeneCards: NKRF

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	No data available	Start	119,588,337 bp^[1]
Band	No data available	End	119,605,895 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	No data available	Start	36,887,540 bp^[2]
Band	No data available	End	36,902,899 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• DNA binding • protein binding • nucleic acid binding • RNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Cellular component	• nucleus • nucleolus
Biological process	• negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55922


77286

Ensembl


ENSG00000186416


ENSMUSG00000044149

UniProt


O15226


Q8BY02

RefSeq (mRNA)


NM_001173487 NM_001173488 NM_017544


NM_029891

RefSeq (protein)


NP_001166958 NP_001166959 NP_060014


NP_084167

Location (UCSC)

Chr X: 119.59 – 119.61 Mb

Chr X: 36.89 – 36.9 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

NF-kappa-B-repressing factor is a protein that in humans is encoded by the NKRF gene.^[5]^[6]

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186416 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044149 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Nourbakhsh M, Hauser H (Jan 2000). "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB". EMBO J. 18 (22): 6415–25. PMC 1171704 . PMID 10562553. doi:10.1093/emboj/18.22.6415.
1 2 "Entrez Gene: NKRF NF-kappaB repressing factor".

Frattini A, Faranda S, Bagnasco L, et al. (1997). "Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25.". Gene. 192 (2): 291–8. PMID 9224902. doi:10.1016/S0378-1119(97)00108-X.
Feng X, Guo Z, Nourbakhsh M, et al. (2002). "Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene.". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14212–7. PMC 137863 . PMID 12381793. doi:10.1073/pnas.212306199.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell. 13 (11): 4100–9. PMC 133617 . PMID 12429849. doi:10.1091/mbc.E02-05-0271.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Jianfeng D, Feng J, Chaoneng J, et al. (2004). "Cloning of the correct full length cDNA of NF-kappaB-repressing factor.". Mol. Cells. 16 (3): 397–401. PMID 14744032.
Niedick I, Froese N, Oumard A, et al. (2005). "Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF.". J. Cell. Sci. 117 (Pt 16): 3447–58. PMID 15226370. doi:10.1242/jcs.01129.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Dreikhausen U, Hiebenthal-Millow K, Bartels M, et al. (2005). "NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor.". Mol. Cell. Biol. 25 (17): 7473–83. PMC 1190279 . PMID 16107696. doi:10.1128/MCB.25.17.7473-7483.2005.
Fukuyama R, Ng KP, Cicek M, et al. (2007). "Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells.". Mol. Carcinog. 46 (5): 402–13. PMID 17186550. doi:10.1002/mc.20288.
Reboll MR, Oumard A, Gazdag AC, et al. (2007). "NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element.". RNA. 13 (8): 1328–40. PMC 1924892 . PMID 17592041. doi:10.1261/rna.545407.

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NKRF (gene)

References

Further reading