NFKBIZ

NFKBIZ
Identifiers
AliasesNFKBIZ, IKBZ, INAP, MAIL, NFKB inhibitor zeta
External IDsMGI: 1931595 HomoloGene: 12734 GeneCards: NFKBIZ
Gene location (Human)
Chr.Chromosome 3 (human)[1]
BandNo data availableStart101,827,991 bp[1]
End101,861,022 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

64332

80859

Ensembl

ENSG00000144802

ENSMUSG00000035356

UniProt

Q9BYH8

Q9EST8

RefSeq (mRNA)

NM_031419
NM_001005474

NM_001159394
NM_001159395
NM_030612

RefSeq (protein)

NP_001005474
NP_113607

NP_001152866
NP_001152867
NP_085115

Location (UCSC)Chr 3: 101.83 – 101.86 MbChr 3: 55.81 – 55.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NF-kappa-B inhibitor zeta is a protein that in humans is encoded by the NFKBIZ gene.[5][6][7]

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000144802 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035356 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Eto A, Muta T, Yamazaki S, Takeshige K (Feb 2003). "Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta". Biochem Biophys Res Commun. 301 (2): 495–501. PMID 12565889. doi:10.1016/S0006-291X(02)03082-6.
  6. ↑ Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Janicke RU, Schulze-Osthoff K (May 2006). "A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding". J Biol Chem. 281 (18): 12645–54. PMID 16513645. doi:10.1074/jbc.M511956200.
  7. 1 2 "Entrez Gene: NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta".

Further reading

  • Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M (2000). "MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production.". FEBS Lett. 485 (1): 53–6. PMID 11086164. doi:10.1016/S0014-5793(00)02185-2. 
  • Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B (2001). "Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene.". Immunogenetics. 53 (8): 649–55. PMID 11797098. doi:10.1007/s00251-001-0376-x. 
  • Haruta H, Kato A, Todokoro K (2001). "Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs.". J. Biol. Chem. 276 (16): 12485–8. PMID 11278262. doi:10.1074/jbc.C100075200. 
  • Yamazaki S, Muta T, Takeshige K (2001). "A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei.". J. Biol. Chem. 276 (29): 27657–62. PMID 11356851. doi:10.1074/jbc.M103426200. 
  • Kitamura H, Kanehira K, Shiina T, Morimatsu M, Jung BD, Akashi S, Saito M (2002). "Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4.". J. Vet. Med. Sci. 64 (5): 419–22. PMID 12069074. doi:10.1292/jvms.64.419. 
  • Kitamura H, Matsushita Y, Iwanaga T, Mori K, Kanehira K, Fujikura D, Morimatsu M, Saito M (2003). "Bacterial lipopolysaccharide-induced expression of the IkappaB protein MAIL in B-lymphocytes and macrophages.". Arch. Histol. Cytol. 66 (1): 53–62. PMID 12703554. doi:10.1679/aohc.66.53. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 Freely accessible. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Shiina T, Konno A, Oonuma T, Kitamura H, Imaoka K, Takeda N, Todokoro K, Morimatsu M (2004). "Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease.". J. Biol. Chem. 279 (53): 55493–8. PMID 15491998. doi:10.1074/jbc.M409770200. 
  • Ito T, Morimatsu M, Oonuma T, Shiina T, Kitamura H, Syuto B (2004). "Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages.". Gene. 342 (1): 137–43. PMID 15527973. doi:10.1016/j.gene.2004.07.032. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Yamamoto M, Yamazaki S, Uematsu S, et al. (2004). "Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.". Nature. 430 (6996): 218–22. PMID 15241416. doi:10.1038/nature02738. 
  • Yamaji D, Kitamura H, Kimura K, Matsushita Y, Okada H, Shiina T, Morimatsu M, Saito M (2004). "Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows.". Vet. Immunol. Immunopathol. 98 (3-4): 175–84. PMID 15010226. doi:10.1016/j.vetimm.2003.12.004. 
  • Yamazaki S, Muta T, Matsuo S, Takeshige K (2005). "Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization.". J. Biol. Chem. 280 (2): 1678–87. PMID 15522867. doi:10.1074/jbc.M409983200. 
  • Motoyama M, Yamazaki S, Eto-Kimura A, et al. (2005). "Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein.". J. Biol. Chem. 280 (9): 7444–51. PMID 15618216. doi:10.1074/jbc.M412738200. 
  • Cowland JB, Muta T, Borregaard N (2006). "IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta.". J. Immunol. 176 (9): 5559–66. PMID 16622025. doi:10.4049/jimmunol.176.9.5559. 
  • Oonuma T, Morimatsu M, Ochiai K, Iwanaga T, Hashizume K (2007). "Role of NF-kappaB in constitutive expression of MAIL in epidermal keratinocytes.". J Vet Med Sci. 69 (3): 279–84. PMID 17409644. doi:10.1292/jvms.69.279. 
  • Matsuo S, Yamazaki S, Takeshige K, Muta T (2007). "Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation.". Biochem. J. 405 (3): 605–15. PMC 2267307 Freely accessible. PMID 17447895. doi:10.1042/BJ20061797. 


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