NAP1L4
Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene.[5][6]
This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.[6]
References
Further reading
- Rodriguez P, Munroe D, Prawitt D, et al. (1997). "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone.". Genomics. 44 (3): 253–65. PMID 9325046. doi:10.1006/geno.1997.4868.
- Rodriguez P, Pelletier J, Price GB, Zannis-Hadjopoulos M (2000). "NAP-2: histone chaperone function and phosphorylation state through the cell cycle.". J. Mol. Biol. 298 (2): 225–38. PMID 10764593. doi:10.1006/jmbi.2000.3674.
- Shikama N, Chan HM, Krstic-Demonacos M, et al. (2000). "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators.". Mol. Cell. Biol. 20 (23): 8933–43. PMC 86548
. PMID 11073993. doi:10.1128/MCB.20.23.8933-8943.2000.
- Cicala C, Arthos J, Selig SM, et al. (2002). "HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication.". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9380–5. PMC 123149 . PMID 12089333. doi:10.1073/pnas.142287999.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Rodriguez P, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2005). "NAP-2 is part of multi-protein complexes in HeLa cells.". J. Cell. Biochem. 93 (2): 398–408. PMID 15368365. doi:10.1002/jcb.20163.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. PMC 1459365 . PMID 16565220. doi:10.1073/pnas.0507066103.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
