NADSYN1

NADSYN1
Identifiers
Aliases	NADSYN1, NAD synthetase 1
External IDs	MGI: 1926164 HomoloGene: 6098 GeneCards: NADSYN1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band No data available Start 71,453,109 bp[1] End 71,524,107 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band No data available Start 143,795,584 bp[2] End 143,822,849 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • ligase activity • protein binding • ATP binding • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds • glutaminase activity • NAD+ synthase (glutamine-hydrolyzing) activity Cellular component • cytoplasm • cytosol Biological process • nitrogen compound metabolic process • NAD metabolic process • NAD biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55191	78914
Ensembl	ENSG00000172890	ENSMUSG00000031090
UniProt	Q6IA69	Q711T7
RefSeq (mRNA)	NM_018161	NM_030221 NM_001308092 NM_001308095
RefSeq (protein)	NP_060631	NP_001295024 NP_084497
Location (UCSC)	Chr 11: 71.45 – 71.52 Mb	Chr 11: 143.8 – 143.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Glutamine-dependent NAD(+) synthetase is an enzyme that in humans is encoded by the NADSYN1 gene.^[5][6]

Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).^[6]

References

Further reading