''N''-Nitrosodiethylamine

N-Nitrosodiethylamine
Names
Preferred IUPAC name
N,N-Diethylnitrous amide
Other names
N-Ethyl-N-nitrosoethanamine
Diethylnitrosamine
DENA
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
EC Number 214-237-4
KEGG
MeSH D004052
Properties
C4H10N2O
Molar mass 102.14 g·mol−1
Appearance Yellow liquid[1]
Density 0.95 g/mL[1]
Boiling point 177 °C (351 °F; 450 K)[1]
-59.3·10−6 cm3/mol
Related compounds
Related compounds
 Diethylamine, N-Nitrosodimethylamine
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

N-Nitrosodiethylamine is a carcinogenic and mutagenic[2] organic compound, classified as a nitrosamine. It is found in tobacco smoke.[3]

It is classified as a Group 2A carcinogen (probable human carcinogen) by the World Health Organization.[4]

N-Nitrosodiethylamine is a constituent of tobacco smoke.[5]


References

  1. 1 2 3 "N-Nitrosodiethylamine". Sigma-Aldrich.
  2. ↑ Verna, L; Whysner, J; Williams, G. M. (1996). "N-nitrosodiethylamine mechanistic data and risk assessment: Bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation". Pharmacology & therapeutics. 71 (1–2): 57–81. PMID 8910949. doi:10.1016/0163-7258(96)00062-9.
  3. ↑ Tricker, A. R.; Ditrich, C; Preussmann, R (1991). "N-nitroso compounds in cigarette tobacco and their occurrence in mainstream tobacco smoke". Carcinogenesis. 12 (2): 257–61. PMID 1995191. doi:10.1093/carcin/12.2.257.
  4. ↑ "List of Classifications, Volumes 1-115". IARC Monographs on the Evaluation of Risk to Humans. International Agency for Research on Cancer. February 22, 2016. Retrieved July 26, 2016.
  5. ↑ Talhout, Reinskje; Schulz, Thomas; Florek, Ewa; Van Benthem, Jan; Wester, Piet; Opperhuizen, Antoon (2011). "Hazardous Compounds in Tobacco Smoke". International Journal of Environmental Research and Public Health. 8 (12): 613–628. ISSN 1660-4601. PMC 3084482 Freely accessible. PMID 21556207. doi:10.3390/ijerph8020613.
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