MTPN

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3AAA

Identifiers

Aliases

MTPN, GCDP, V-1, myotrophin

External IDs

MGI: 99445 HomoloGene: 40607 GeneCards: MTPN

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	No data available	Start	135,926,761 bp^[1]
Band	No data available	End	135,977,353 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	No data available	Start	35,508,906 bp^[2]
Band	No data available	End	35,539,888 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• sequence-specific DNA binding
Cellular component	• cytoplasm • F-actin capping protein complex • axon • perinuclear region of cytoplasm • extracellular exosome • nucleus • cytosol
Biological process	• regulation of striated muscle tissue development • catecholamine metabolic process • positive regulation of cardiac muscle hypertrophy • regulation of barbed-end actin filament capping • cell growth • cellular response to mechanical stimulus • skeletal muscle tissue regeneration • neuron differentiation • striated muscle cell differentiation • regulation of translation • cerebellar granule cell differentiation • positive regulation of NF-kappaB transcription factor activity • positive regulation of protein metabolic process • positive regulation of cell growth • positive regulation of macromolecule biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


136319


14489

Ensembl


ENSG00000105887


ENSMUSG00000029840

UniProt


P58546


P62774

RefSeq (mRNA)


NM_145808


NM_008098

RefSeq (protein)


NP_665807


NP_032124

Location (UCSC)

Chr 7: 135.93 – 135.98 Mb

Chr 7: 35.51 – 35.54 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myotrophin is a protein that in humans is encoded by the MTPN gene.^[5]^[6]

Interactions

MTPN has been shown to interact with RELA^[7] and REL.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105887 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029840 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Mitra S, Timur AA, Gupta S, Wang Q, Sen S (July 2001). "Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization". Cytogenet Cell Genet. 93 (1–2): 151–2. PMID 11474205. doi:10.1159/000056974.
↑ "Entrez Gene: MTPN myotrophin".
1 2 Knuefermann, Pascal; Chen Peter; Misra Arunima; Shi Shu-Ping; Abdellatif Maha; Sivasubramanian Natarajan (June 2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. United States. 277 (26): 23888–97. ISSN 0021-9258. PMID 11971907. doi:10.1074/jbc.M202937200.

Taoka M, Yamakuni T, Song SY, et al. (1992). "A rat cerebellar protein containing the cdc10/SWI6 motif". Eur. J. Biochem. 207 (2): 615–20. PMID 1633812. doi:10.1111/j.1432-1033.1992.tb17088.x.
Sil P, Misono K, Sen S (1993). "Myotrophin in human cardiomyopathic heart". Circ. Res. 73 (1): 98–108. PMID 8508536. doi:10.1161/01.res.73.1.98.
Sivasubramanian N, Adhikary G, Sil PC, Sen S (1996). "Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro". J. Biol. Chem. 271 (5): 2812–6. PMID 8576259. doi:10.1074/jbc.271.5.2812.
Anderson KM, Berrebi-Bertrand I, Kirkpatrick RB, et al. (1999). "cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy". J. Mol. Cell. Cardiol. 31 (4): 705–19. PMID 10329199. doi:10.1006/jmcc.1998.0903.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
Knuefermann P, Chen P, Misra A, et al. (2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. 277 (26): 23888–97. PMID 11971907. doi:10.1074/jbc.M202937200.
Gupta S, Sen S (2002). "Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy". Biochim. Biophys. Acta. 1589 (3): 247–60. PMID 12031792. doi:10.1016/S0167-4889(02)00178-7.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
Xiong Z, Liu E, Yan Y, et al. (2006). "An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions". J. Immunol. 177 (7): 4907–16. PMID 16982933. doi:10.4049/jimmunol.177.7.4907.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

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MTPN

Interactions

References

Further reading