Triprolidine

Triprolidine
Clinical data
Trade names Actidil, Myidil, Actifed (in the latter combined with pseudoephedrine and either dextromethorphan or guaifenesin)
AHFS/Drugs.com Monograph
Pregnancy
category
  • C (US)
Routes of
administration		 Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 4% oral
Protein binding 90%
Metabolism Hepatic (CYP2D6)
Biological half-life 4-6 hours
Excretion Renal
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.006.934
Chemical and physical data
Formula C19H22N2
Molar mass 278.391 g/mol
3D model (JSmol)
Melting point 60 °C (140 °F)
Solubility in water 500 mg/mL (20 °C)
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Triprolidine is an over-the-counter antihistamine with anticholinergic properties.[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.[2] Like many antihistamines, the most common side effect is drowsiness.[1] Triprolidine is a quick acting drug that can clear congestion and stop runny noses in 15–30 minutes.

References

  1. 1 2 Goldsmith, P.; Dowd, P. M. (1993). "The new H1 antihistamines. Treatment of urticaria and other clinical problems". Dermatologic clinics. 11 (1): 87–95. PMID 8094649.
  2. ↑ Williams, B. O.; Liao, S. H.; Lai, A. A.; Arnold, J. D.; Perkins, J. G.; Blum, M. R.; Findlay, J. W. (1984). "Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products". Clinical pharmacy. 3 (6): 638–643. PMID 6509877.


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