Monolysocardiolipin

Molecular structure of MLCL backbone.

Monolysocardiolipin (MLCL) is a phospholipid with three fatty acid chains located in the inner membrane of mitochondria.

MLCL is normally present as part of the metabolic cycle of mitochondrial lipids, such as cardiolipin.[1] It is remodeled by the enzymes monolysocardiolipin acyltransferase, lysocardiolipin acyltransferase, and tafazzin, which transfer a fourth fatty acid chain onto the phospholipid.[2]

References

  1. ↑ Ma BJ, Taylor WA, Dolinsky VW, Hatch GM (1999). "Acylation of monolysocardiolipin in rat heart.". J Lipid Res. 40 (10): 1837–45. PMID 10508203.
  2. ↑ Taylor, W. A.; Hatch, G. M. (2009). "Identification of the Human Mitochondrial Linoleoyl-coenzyme A Monolysocardiolipin Acyltransferase (MLCL AT-1)". Journal of Biological Chemistry. 284 (44): 30360–30371. ISSN 0021-9258. PMC 2781591 Freely accessible. PMID 19737925. doi:10.1074/jbc.M109.048322.


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