Denticity

Atom with
monodentate ligands

Denticity refers to the number of donor groups in a single ligand that bind to a central atom in a coordination complex.[1][2] In many cases, only one atom in the ligand binds to the metal, so the denticity equals one, and the ligand is said to be monodentate (sometimes called unidentate). Ligands with more than one bonded atom are called polydentate or multidentate. The word denticity is derived from dentis, the Latin word for tooth. The ligand is thought of as biting the metal at one or more linkage points. The denticity of a ligand is described with the Greek letter κ ('kappa').[3] For example, κ6-EDTA describes an EDTA ligand that coordinates through 6 non-contiguous atoms.

Denticity is different from hapticity because hapticity refers exclusively to ligands where the coordinating atoms are contiguous. In these cases the η ('eta') notation is used.[4] Bridging ligands use the μ ('mu') notation.[5][6]

Classes

Polydentate ligands are chelating agents[7] and classified by their denticity. Some atoms cannot form the maximum possible number of bonds a ligand could make. In that case one or more binding sites of the ligand are unused. Such sites can be used to form a bond with another chemical species.

Structure of the pharmaceutical Oxaliplatin, which features two different bidentate ligands.
Relationship between "linear" bi-, tri- and tetradentate ligands (red) bound to an octahedral metal center. The structures marked with * are chiral owing to the backbone of the tetradentate ligand.

Stability constants

In general, the stability of a metal complex correlates with the denticity of the ligands. The stability of a complex is represented quantitatively in the form of Stability constants. Hexadentate ligands tend to bind metal ions more strongly than ligands of lower denticity.

See also

References

  1. IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version:  (2006) "denticity".
  2. von Zelewsky, A. "Stereochemistry of Coordination Compounds" John Wiley: Chichester, 1995. ISBN 047195599X.
  3. http://goldbook.iupac.org/K03366.html
  4. http://goldbook.iupac.org/H01881.html
  5. http://goldbook.iupac.org/B00741.html>
  6. http://goldbook.iupac.org/M03659.html
  7. IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version:  (2006) "chelation".
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