Mitogen-activated protein kinase 9

MAPK9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E7O, 3NPC
Identifiers
Aliases	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK, mitogen-activated protein kinase 9
External IDs	OMIM: 602896 MGI: 1346862 HomoloGene: 55685 GeneCards: MAPK9
Gene location (Human) Chr. Chromosome 5 (human)[1] Band No data available Start 180,233,143 bp[1] End 180,292,099 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band No data available Start 49,846,751 bp[2] End 49,886,421 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • MAP kinase activity • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • transcription factor binding • JUN kinase activity Cellular component • cytosol • nucleoplasm • mitochondrion • nucleus • cytoplasm • neuron projection Biological process • response to cadmium ion • phosphorylation • rhythmic process • response to stress • positive regulation of apoptotic signaling pathway • positive regulation of podosome assembly • Fc-epsilon receptor signaling pathway • protein phosphorylation • positive regulation of macrophage derived foam cell differentiation • positive regulation of gene expression • JUN phosphorylation • regulation of sequence-specific DNA binding transcription factor activity • regulation of circadian rhythm • JNK cascade • response to mechanical stimulus • positive regulation of apoptotic process • neuron development • cellular response to organic substance • protein localization to tricellular tight junction • peptidyl-serine phosphorylation • cellular response to reactive oxygen species • cellular response to cadmium ion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5601	26420
Ensembl	ENSG00000050748	ENSMUSG00000020366
UniProt	P45984	Q9WTU6
RefSeq (mRNA)	NM_001135044 NM_001308244 NM_002752 NM_139068 NM_139069 NM_139070	NM_001163671 NM_001163672 NM_016961 NM_207692
RefSeq (protein)	NP_001128516 NP_001295173 NP_002743 NP_620707 NP_620708 NP_620709	NP_001157143 NP_001157144 NP_058657 NP_997575
Location (UCSC)	Chr 5: 180.23 – 180.29 Mb	Chr 5: 49.85 – 49.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.^[5]

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation-induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.^[6]

Interactions

Mitogen-activated protein kinase 9 has been shown to interact with:

• Grb2,^[7][8]
• MAPK8IP1,^[9][10]
• MAPK8IP2,^[9]
• MAPK8IP3^[11][12]
• P53,^[13][14] and
• TOB1.^[15]

References

Further reading

External links

• MAP Kinase Resource .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.