Mitochondrial translational release factor 1
| MTRF1 | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | MTRF1, MRF1, MTTRF1, RF1, mitochondrial translational release factor 1, mitochondrial translation release factor 1 | ||||||||||||||||
| External IDs | MGI: 2384815 HomoloGene: 20903 GeneCards: MTRF1 | ||||||||||||||||
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| Orthologs | |||||||||||||||||
| Species | Human | Mouse | |||||||||||||||
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| Ensembl | |||||||||||||||||
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| RefSeq (mRNA) | |||||||||||||||||
| RefSeq (protein) | |||||||||||||||||
| Location (UCSC) | Chr 13: 41.22 – 41.26 Mb | Chr 14: 79.4 – 79.42 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
| Wikidata | |||||||||||||||||
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Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.[3][4]
The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Zhang Y, Spremulli LL (November 1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta. 1443 (1-2): 245–50. PMID 9838146. doi:10.1016/S0167-4781(98)00223-1.
- ↑ Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1-2): 91–2. PMID 10773675. doi:10.1159/000015494.
Further reading
- Nozaki Y, Matsunaga N, Ishizawa T, et al. (2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG.". Genes Cells. 13 (5): 429–38. PMID 18429816. doi:10.1111/j.1365-2443.2008.01181.x.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature. 428 (6982): 522–8. PMC 2665288
. PMID 15057823. doi:10.1038/nature02379. - Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Research. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nature Genetics. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proceedings of the National Academy of Sciences. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Soleimanpour-Lichaei HR, Kühl I, Gaisne M, et al. (2007). "mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG.". Molecular Cell. 27 (5): 745–57. PMC 1976341 . PMID 17803939. doi:10.1016/j.molcel.2007.06.031.
- Young DJ, Edgar CD, Murphy J, et al. (2010). "Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria.". RNA. 16 (6): 1146–55. PMC 2874167 . PMID 20421313. doi:10.1261/rna.1970310.
- Huynen, MA, Martijn; Duarte I; Chrzanowska-Lightowlers ZM; Nabuurs SB. (8 May 2012). "Structure based hypothesis of a mitochondrial ribosome rescue mechanism.". Biology Direct. 7 (1): 14. PMC 3418547 . PMID 22569235. doi:10.1186/1745-6150-7-14.
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