mir-BHRF1-3 microRNA precursor family

mir-BHRF1-3 microRNA precursor family

Predicted secondary structure and sequence conservation of mir-BHRF1-3
Identifiers
Symbol mir-BHRF1-3
Rfam RF00367
Other data
RNA type Gene; miRNA
Domain(s) Viruses
GO 0035195 0035068
SO 0001244

The mir-BHRF1-3 microRNA precursor found in Human herpesvirus 4 (Epstein-Barr virus). In Epstein-Barr virus, mir-BHRF1-3 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 5' arm of the hairpin.[1] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-1 and Mir-BHRF1-2.[1]

BHRF-1-3 miRNA is thought to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein-Barr virus genome.[2] BHRF-3 has been shown to be expressed in latency-III infected lymphoblasts.[3]

References

  1. 1 2 Pfeffer, S; Zavolan M; Grasser FA; Chien M; Russo JJ; Ju J; John B; Enright AJ; Marks D; Sander C; Tuschl T (2004). "Identification of Virus-Encoded MicroRNAs". Science. 304 (5671): 734–736. PMID 15118162. doi:10.1126/science.1096781.
  2. ↑ Feederle, R; Haar, J; Bernhardt, K; Linnstaedt, SD; Bannert, H; Lips, H; Cullen, BR; Delecluse, HJ (Jul 13, 2011). "The members of a viral miRNA cluster co-operate to transform B lymphocytes.". Journal of Virology. 85 (19): 9801–10. PMC 3196389 Freely accessible. PMID 21752900. doi:10.1128/JVI.05100-11.
  3. ↑ Xing, L; Kieff, E (September 2007). "Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication.". Journal of Virology. 81 (18): 9967–75. PMC 2045418 Freely accessible. PMID 17626073. doi:10.1128/JVI.02244-06.


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