MiR-206

The structure of pre-miR-206 as determined by RNA folding algorithms

MiR-206 is a microRNA that in humans is a member of the myomiR family which also includes miR-1, miR-133, miR-208a/b among few others.[1][2][3][4]

As well as being regulated during the embryonic development of skeletal muscle, miR-206 is regulated by estradiol.[5][6] C2C12 myoblast cells are widely used as a model for the study of cell differentiation in skeletal muscle. Furthermore, miR-206 is highly expressed in triple-negative breast tumors that grow independent of estradiol, and miR-206 is a predictor of worse overall survival in breast cancer patients.[7]

The biogenesis of miR-206 is unique in that the primary mature transcript is generated from the 3p arm of the precursor hairpin rather than the 5p arm.[8]

References

  1. ↑ Sempere, Lorenzo F.; Freemantle, Sarah; Pitha-Rowe, Ian; Moss, Eric; Dmitrovsky, Ethan; Ambros, Victor (2004). "Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation". Genome Biology. 5 (3): R13. PMC 395763 Freely accessible. PMID 15003116. doi:10.1186/gb-2004-5-3-r13.
  2. ↑ van Rooij, Eva; Quiat, Daniel; Johnson, Brett A.; Sutherland, Lillian B.; Qi, Xiaoxia; Richardson, James A.; Kelm, Robert J.; Olson, Eric N. (November 2009). "A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance". Developmental Cell. 17 (5): 662–673. PMC 2796371 Freely accessible. PMID 19922871. doi:10.1016/j.devcel.2009.10.013.
  3. ↑ Small, Eric M.; O'Rourke, Jason R.; Moresi, Viviana; Sutherland, Lillian B.; McAnally, John; Gerard, Robert D.; Richardson, James A.; Olson, Eric N. (2010-03-02). "Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486". Proceedings of the National Academy of Sciences of the United States of America. 107 (9): 4218–4223. PMC 2840099 Freely accessible. PMID 20142475. doi:10.1073/pnas.1000300107.
  4. ↑ van Rooij, Eva; Sutherland, Lillian B.; Qi, Xiaoxia; Richardson, James A.; Hill, Joseph; Olson, Eric N. (2007-04-27). "Control of stress-dependent cardiac growth and gene expression by a microRNA". Science. 316 (5824): 575–579. PMID 17379774. doi:10.1126/science.1139089.
  5. ↑ Adams, Brian D.; Furneaux, Henry; White, Bruce A. (May 2007). "The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines". Molecular Endocrinology (Baltimore, Md.). 21 (5): 1132–1147. PMID 17312270. doi:10.1210/me.2007-0022.
  6. ↑ Adams, Brian D.; Cowee, Danielle M.; White, Bruce A. (August 2009). "The role of miR-206 in the epidermal growth factor (EGF) induced repression of estrogen receptor-alpha (ERalpha) signaling and a luminal phenotype in MCF-7 breast cancer cells". Molecular Endocrinology (Baltimore, Md.). 23 (8): 1215–1230. PMC 2718747 Freely accessible. PMID 19423651. doi:10.1210/me.2009-0062.
  7. ↑ Kondo, Naoto; Toyama, Tatsuya; Sugiura, Hiroshi; Fujii, Yoshitaka; Yamashita, Hiroko (2008-07-01). "miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer". Cancer Research. 68 (13): 5004–5008. PMID 18593897. doi:10.1158/0008-5472.CAN-08-0180.
  8. ↑ Kozomara, Ana; Griffiths-Jones, Sam (2014-01-01). "miRBase: annotating high confidence microRNAs using deep sequencing data". Nucleic Acids Research. 42 (D1): D68–D73. ISSN 0305-1048. PMC 3965103 Freely accessible. PMID 24275495. doi:10.1093/nar/gkt1181.
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