mir-17 microRNA precursor family

mir-17 microRNA precursor family

Identifiers
Symbol mir-17
Rfam RF00051
miRBase MI0000071
miRBase family MIPF0000001
Other data
RNA type Gene; miRNA
Domain(s) Eukaryota
GO 0035195 0035068
SO 0001244

The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression. The microRNA precursor miR-17 family, includes miR-20a/b, miR-93, and miR-106a/b. With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary genetic duplication events, and also include members of the miR-19, and miR-25 families.[1] These clusters are transcribed as long non-coding RNA transcripts that are processed to form ~70 nucleotide microRNA precursors, that are subsequently processed by the Dicer enzyme to give a ~22 nucleotide products. The mature microRNA products are thought to regulate expression levels of other genes through complementarity to the 3' UTR of specific target messenger RNA.[2][3]

The paralogous miRNA gene clusters that give rise to miR-17 family microRNAs (miR-17~92, miR-106a~363, and miR-106b~25) have been implicated in a wide variety of malignancies and are sometimes referred to as oncomirs.[4] The oncogenic potential of these non-protein encoding genes was first identified in mouse viral tumorigenesis screens.[5][6][7] In humans, the activating mutations of miR-17~92 have been identified in non-Hodgkin's lymphoma, whereas the miRNA constituents of the clusters are overexpressed in a multiple cancer types.[8][9][10] High level expression of miR-17 family members induces cell proliferation, whereas deletion of the miR-17~92 cluster, in mice, is lethal and causes lung and lymphoid cell developmental defects.[11] In addition, in the nasopharyngeal carcinoma cell line, miR-20a and miR-20b has been shown to target the 3’ UTR of vascular endothelial growth factor (VEGF) and repress the expression of VEGF, which is an important angiogenic factor.[12][13]

References

  1. ↑ Tanzer A, Stadler PF (2004). "Molecular evolution of a microRNA cluster.". J Mol Biol. 339: 327–35. PMID 15136036. doi:10.1016/j.jmb.2004.03.065.
  2. ↑ Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs.". Science. 294 (5543): 853–8. PMID 11679670. doi:10.1126/science.1064921.
  3. ↑ Ambros V (2001). "microRNAs: tiny regulators with great potential.". Cell. 107 (7): 823–6. PMID 11779458. doi:10.1016/S0092-8674(01)00616-X.
  4. ↑ Hammond, SM. (Nov 2006). "RNAi, microRNAs, and human disease.". Cancer Chemother Pharmacol. 58 Suppl 1: s63–8. PMID 17093929. doi:10.1007/s00280-006-0318-2.
  5. ↑ Hwang HC, Martins CP, Bronkhorst Y, Randel E, Berns A, Fero ML, Clurman BE (2002). "Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.". Proc Natl Acad Sci U S A. 99 (17): 11293–8. PMC 123250 Freely accessible. PMID 12151601. doi:10.1073/pnas.162356099.
  6. ↑ Wang CL, Wang BB, Bartha G, Li L, Channa N, Klinger M, Killeen N, Wabl M (2006). "Activation of an oncogenic microRNA cistron by provirus integration.". Proc Natl Acad Sci U S A. 103 (49): 18680–4. PMC 1693722 Freely accessible. PMID 17121985. doi:10.1073/pnas.0609030103.
  7. ↑ Landais S, Landry S, Legault P, Rassart E (2007). "Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia.". Cancer Res. 67 (12): 5699–707. PMID 17575136. doi:10.1158/0008-5472.CAN-06-4478.
  8. ↑ Ota A, Tagawa H, Karnan S, Tsuzuki S, Karpas A, Kira S, Yoshida Y, Seto M (2004). "Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.". Cancer Res. 64 (9): 3087–95. PMID 15126345. doi:10.1158/0008-5472.CAN-03-3773.
  9. ↑ Rinaldi A, Poretti G, Kwee I, Zucca E, Catapano CV, Tibiletti MG, Bertoni F (2007). "Concomitant MYC and microRNA cluster miR-17-92 (C13orf25) amplification in human mantle cell lymphoma.". Leuk Lymphoma. 48 (2): 410–2. PMID 17325905. doi:10.1080/10428190601059738.
  10. ↑ Mendell JT (2008). "miRiad roles for the miR-17-92 cluster in development and disease.". Cell. 133 (2): 217–22. PMC 2732113 Freely accessible. PMID 18423194. doi:10.1016/j.cell.2008.04.001.
  11. ↑ Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, et al. (2008). "Targeted deletion reveals essential and overlapping functions of the miR-17~92 family of miRNA clusters.". Cell. 132 (5): 875–86. PMC 2323338 Freely accessible. PMID 18329372. doi:10.1016/j.cell.2008.02.019.
  12. ↑ Hua Z, Lv Q, Ye W, Wong CK, Cai G, Gu D, Ji Y, Zhao C, Wang J, Yang BB, Zhang Y (Dec 27, 2006). "MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia". PLOS ONE. 1 (1): e116. PMC 1762435 Freely accessible. PMID 17205120. doi:10.1371/journal.pone.0000116.
  13. ↑ Ye W, Lv Q, Wong CK, Hu S, Fu C, Hua Z, Cai G, Li G, Yang BB, Zhang Y (Mar 5, 2008). "The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation". PLOS ONE. 3 (3): e1719. PMC 2248708 Freely accessible. PMID 18320040. doi:10.1371/journal.pone.0001719.

Further reading

  1. ↑ Dews M, Fox JL, Hultine S, Sundaram P, Wang W, Liu YY, Furth E, Enders GH, El-Deiry W, Schelter JM, Cleary MA, Thomas-Tikhonenko A (2010). "The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.". Cancer Res. 70 (20): 8233–46. PMID 20940405. doi:10.1158/0008-5472.CAN-10-2412.
  2. ↑ Xiang J, Wu J (2010). "Feud or Friend? The Role of the miR-17-92 Cluster in Tumorigenesis.". Curr Genomics. 11 (2): 129–35. PMC 2874222 Freely accessible. PMID 20885820. doi:10.2174/138920210790886853.
  3. ↑ Wang Z, Liu M, Zhu H, Zhang W, He S, Hu C, Quan L, Bai J, Xu N (2010). "Suppression of p21 by c-Myc through members of miR-17 family at the post-transcriptional level.". Int J Oncol. 37 (5): 1315–21. PMID 20878079. doi:10.3892/ijo_00000783.
  4. ↑ Hong L, Lai M, Chen M, Xie C, Liao R, Kang YJ, Xiao C, Hu WY, Han J, Sun P (2010). "The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence.". Cancer Res. 70 (21): 8547–57. PMC 2970743 Freely accessible. PMID 20851997. doi:10.1158/0008-5472.CAN-10-1938.
  5. ↑ Osada H, Takahashi T (2010). "Review Article: let-7 and miR-17-92: Small-sized major players in lung cancer development.". Cancer Sci. 102 (1): 9–17. PMID 20735434. doi:10.1111/j.1349-7006.2010.01707.x.
  6. ↑ Cox MB, Cairns MJ, Gandhi KS, Carroll AP, Moscovis S, Stewart GJ, Broadley S, Scott RJ, Booth DR, Lechner-Scott J, ANZgene Multiple Sclerosis Genetics Consortium (2010). Jacobson S, ed. "MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood.". PLoS ONE. 5 (8): e12132. PMC 2920328 Freely accessible. PMID 20711463. doi:10.1371/journal.pone.0012132.
  7. ↑ Yu J, Ohuchida K, Mizumoto K, Fujita H, Nakata K, Tanaka M (2010). "MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis and involved in cancer cell proliferation and invasion.". Cancer Biol Ther. 10 (8): 748. PMID 20703102. doi:10.4161/cbt.10.8.13083.
  8. ↑ Zhuo de X, Niu XH, Chen YC, Xin DQ, Guo YL, Mao ZB (2010). "Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts.". J Biol Chem. 285 (41): 31491–501. PMC 2951223 Freely accessible. PMID 20656682. doi:10.1074/jbc.M109.068387.
  9. ↑ Kuhnert F, Kuo CJ (2010). "miR-17-92 angiogenesis micromanagement.". Blood. 115 (23): 4631–3. PMID 20538815. doi:10.1182/blood-2010-03-276428.
  10. ↑ Li H, Bian C, Liao L, Li J, Zhao RC (2010). "miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1.". Breast Cancer Res Treat. 126 (3): 565–575. PMID 20505989. doi:10.1007/s10549-010-0954-4.
  11. ↑ Budde H, Schmitt S, Fitzner D, Opitz L, Salinas-Riester G, Simons M (2010). "Control of oligodendroglial cell number by the miR-17-92 cluster". Development. 137 (13): 2127–32. PMID 20504959. doi:10.1242/dev.050633.
  12. ↑ Grillari J, Hackl M, Grillari-Voglauer R (2010). "miR-17-92 cluster: ups and downs in cancer and aging". Biogerontology. 11 (4): 501–6. PMC 2899009 Freely accessible. PMID 20437201. doi:10.1007/s10522-010-9272-9.
  13. ↑ Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML (2010). "The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression". Cancer Res. 70 (9): 3833–42. PMC 2862107 Freely accessible. PMID 20406979. doi:10.1158/0008-5472.CAN-09-3268.
  14. ↑ Ernst A, Campos B, Meier J, Devens F, Liesenberg F, Wolter M, Reifenberger G, Herold-Mende C, Lichter P, Radlwimmer B (2010). "De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures". Oncogene. 29 (23): 3411–22. PMID 20305691. doi:10.1038/onc.2010.83.
  15. ↑ He S, Yang S, Deng G, Liu M, Zhu H, Zhang W, Yan S, Quan L, Bai J, Xu N (2010). "Aurora kinase A induces miR-17-92 cluster through regulation of E2F1 transcription factor". Cell Mol Life Sci. 67 (12): 2069–76. PMID 20300951. doi:10.1007/s00018-010-0340-8.
  16. ↑ Olive V, Jiang I, He L (2010). "mir-17-92, a cluster of miRNAs in the midst of the cancer network". Int J Biochem Cell Biol. 42 (8): 1348–54. PMID 20227518. doi:10.1016/j.biocel.2010.03.004.
  17. ↑ Tran U, Zakin L, Schweickert A, Agrawal R, Döger R, Blum M, De Robertis EM, Wessely O (2010). "The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity". Development. 137 (7): 1107–16. PMC 2835326 Freely accessible. PMID 20215348. doi:10.1242/dev.046045.
  18. ↑ Yang F, Yin Y, Wang F, Wang Y, Zhang L, Tang Y, Sun S (2010). "miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway". Hepatology. 51 (5): 1614–23. PMID 20209605. doi:10.1002/hep.23566.
  19. ↑ Sasaki K, Kohanbash G, Hoji A, Ueda R, McDonald HA, Reinhart TA, Martinson J, Lotze MT, Marincola FM, Wang E, Fujita M, Okada H (2010). "miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy". J Transl Med. 8 (1): 17. PMC 2836279 Freely accessible. PMID 20167088. doi:10.1186/1479-5876-8-17.
  20. ↑ Lindberg RL, Hoffmann F, Mehling M, Kuhle J, Kappos L (2010). "Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients". Eur J Immunol. 40 (3): 888–98. PMID 20148420. doi:10.1002/eji.200940032.
  21. ↑ Mi S, Li Z, Chen P, He C, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, Thirman MJ, Mulloy JC, Liu PP, Rowley JD, Chen J (2010). "Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia". Proc Natl Acad Sci U S A. 107 (8): 3710–5. PMC 2840429 Freely accessible. PMID 20133587. doi:10.1073/pnas.0914900107.
  22. ↑ Hackl M, Brunner S, Fortschegger K, Schreiner C, Micutkova L, Mück C, Laschober GT, Lepperdinger G, Sampson N, Berger P, Herndler-Brandstetter D, Wieser M, Kühnel H, Strasser A, Rinnerthaler M, Breitenbach M, Mildner M, Eckhart L, Tschachler E, Trost A, Bauer JW, Papak C, Trajanoski Z, Scheideler M, Grillari-Voglauer R, Grubeck-Loebenstein B, Jansen-Dürr P, Grillari J (2010). "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging". Aging Cell. 9 (2): 291–6. PMC 2848978 Freely accessible. PMID 20089119. doi:10.1111/j.1474-9726.2010.00549.x.
  23. ↑ van Haaften G, Agami R (2010). "Tumorigenicity of the miR-17-92 cluster distilled". Genes Dev. 24 (1): 1–4. PMC 2802185 Freely accessible. PMID 20047995. doi:10.1101/gad.1887110.
  24. ↑ Chow TF, Mankaruos M, Scorilas A, Youssef Y, Girgis A, Mossad S, Metias S, Rofael Y, Honey RJ, Stewart R, Pace KT, Yousef GM (2010). "The miR-17-92 cluster is over expressed in and has an oncogenic effect on renal cell carcinoma". J Urol. 183 (2): 743–51. PMID 20022054. doi:10.1016/j.juro.2009.09.086.
  25. ↑ Olive V, Bennett MJ, Walker JC, Ma C, Jiang I, Cordon-Cardo C, Li QJ, Lowe SW, Hannon GJ, He L (2009). "miR-19 is a key oncogenic component of mir-17-92". Genes Dev. 23 (24): 2839–49. PMC 2800084 Freely accessible. PMID 20008935. doi:10.1101/gad.1861409.
  26. ↑ Mu P, Han YC, Betel D, Yao E, Squatrito M, Ogrodowski P, de Stanchina E, D'Andrea A, Sander C, Ventura A (2009). "Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas". Genes Dev. 23 (24): 2806–11. PMC 2800095 Freely accessible. PMID 20008931. doi:10.1101/gad.1872909.
  27. ↑ Guo L, Sun B, Sang F, Wang W, Lu Z (2009). Poon AF, ed. "Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis". PLoS ONE. 4 (11): e7944. PMC 2775919 Freely accessible. PMID 19956752. doi:10.1371/journal.pone.0007944.
  28. ↑ ZHANG ZW, AN Y, TENG CB (2009). "[The roles of miR-17-92 cluster in mammal development and tumorigenesis]". Yi Chuan. 31 (11): 1094–100. PMID 19933089.
  29. ↑ Sun H, Li QW, Lv XY, Ai JZ, Yang QT, Duan JJ, Bian GH, Xiao Y, Wang YD, Zhang Z, Liu YH, Tan RZ, Yang Y, Wei YQ, Zhou Q (2010). "MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation". Mol Biol Rep. 37 (6): 2951–8. PMID 19821056. doi:10.1007/s11033-009-9861-3.
  30. ↑ Yan HL, Xue G, Mei Q, Wang YZ, Ding FX, Liu MF, Lu MH, Tang Y, Yu HY, Sun SH (2009). "Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis". EMBO J. 28 (18): 2719–32. PMC 2750010 Freely accessible. PMID 19696742. doi:10.1038/emboj.2009.214.
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  35. ↑ Carraro G, El-Hashash A, Guidolin D, Tiozzo C, Turcatel G, Young BM, De Langhe SP, Bellusci S, Shi W, Parnigotto PP, Warburton D (2009). "miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution". Dev Biol. 333 (2): 238–50. PMC 2735610 Freely accessible. PMID 19559694. doi:10.1016/j.ydbio.2009.06.020.
  36. ↑ Northcott PA, Fernandez-L A, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, Kenney AM, Taylor MD (2009). "The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors". Cancer Res. 69 (8): 3249–55. PMC 2836891 Freely accessible. PMID 19351822. doi:10.1158/0008-5472.CAN-08-4710.
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  49. ↑ Takakura S, Mitsutake N, Nakashima M, Namba H, Saenko VA, Rogounovitch TI, Nakazawa Y, Hayashi T, Ohtsuru A, Yamashita S (2008). "Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells". Cancer Sci. 99 (6): 1147–54. PMID 18429962. doi:10.1111/j.1349-7006.2008.00800.x.
  50. ↑ Mendell JT (2008). "miRiad roles for the miR-17-92 cluster in development and disease". Cell. 133 (2): 217–22. PMC 2732113 Freely accessible. PMID 18423194. doi:10.1016/j.cell.2008.04.001.
  51. ↑ Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks T (2008). "Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters". Cell. 132 (5): 875–86. PMC 2323338 Freely accessible. PMID 18329372. doi:10.1016/j.cell.2008.02.019.
  52. ↑ Xiao C, Srinivasan L, Calado DP, Patterson HC, Zhang B, Wang J, Henderson JM, Kutok JL, Rajewsky K (2008). "Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes". Nat Immunol. 9 (4): 405–14. PMC 2533767 Freely accessible. PMID 18327259. doi:10.1038/ni1575.
  53. ↑ Wang Q, Li YC, Wang J, Kong J, Qi Y, Quigg RJ, Li X (2008). "miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130". Proc Natl Acad Sci U S A. 105 (8): 2889–94. PMC 2268555 Freely accessible. PMID 18287052. doi:10.1073/pnas.0800178105.
  54. ↑ Xu W, Li JY, Shen QD, Li L, Yu H (2007). "[DNA sequencing of miR-17-92 cluster at chromosome 13q31-q32 in mantel cell lymphoma cell lines]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 15 (5): 986–8. PMID 17956675.
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