mir-145

MIR145
Identifiers
AliasesMIR145, microRNA 145, MIRN145, miR-145, miRNA145
External IDsGeneCards: MIR145
Gene location (Human)
Chr.Chromosome 5 (human)[1]
BandNo data availableStart149,430,646 bp[1]
End149,430,733 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

406937

n/a

Ensembl

ENSG00000276365

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 5: 149.43 – 149.43 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human
mir-145

Conserved secondary structure of mir-145
Identifiers
Symbol mir-145
Rfam RF00675
miRBase family MIPF0000079
Other data
RNA type microRNA
Domain(s) Eukaryota;
SO {{{SO}}}

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.[3]

Targets

MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin.[4] Larsson et al.[5] showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.[6]

Role in cancer

miR-145 is hypothesised to be a tumor suppressor.[7] miR-145 has been shown to be down-regulated in breast cancer.[4] miR-145 is also involved in colon cancer [6][8][9] and acute myeloid leukemia.[10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000276365 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Entrez Gene: MicroRNA 145". Retrieved 2015-01-26.
  4. 1 2 Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, Ibrahim SA, Peddibhotla S, Teng YH, Low JY, Ebnet K, Kiesel L, Yip GW (Dec 2010). "miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene. 29 (50): 6569–80. PMID 20818426. doi:10.1038/onc.2010.386.
  5. ↑ Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genové G, Arrondel C, Gerwins P, Kurschat C, Schermer B, Benzing T, Harvey SJ, Kreuger J, Lindahl P (2009). "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1". Genome Medicine. 1 (11): 108. PMC 2808743 Freely accessible. PMID 19917099. doi:10.1186/gm108.
  6. 1 2 Zhang J, Guo H, Zhang H, Wang H, Qian G, Fan X, Hoffman AR, Hu JF, Ge S (Jan 2011). "Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene". Cancer. 117 (1): 86–95. PMC 2995010 Freely accessible. PMID 20737575. doi:10.1002/cncr.25522.
  7. ↑ Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY (Mar 2009). "p53 represses c-Myc through induction of the tumor suppressor miR-145". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3207–12. PMC 2651330 Freely accessible. PMID 19202062. doi:10.1073/pnas.0808042106.
  8. ↑ Slaby O, Svoboda M, Fabian P, Smerdova T, Knoflickova D, Bednarikova M, Nenutil R, Vyzula R (2007). "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer". Oncology. 72 (5-6): 397–402. PMID 18196926. doi:10.1159/000113489.
  9. ↑ Mazza, Tommaso; Mazzoccoli, Gianluigi; Fusilli, Caterina; Capocefalo, Daniele; Panza, Anna; Biagini, Tommaso; Castellana, Stefano; Gentile, Annamaria; De Cata, Angelo (2016-05-19). "Multifaceted enrichment analysis of RNA-RNA crosstalk reveals cooperating micro-societies in human colorectal cancer". Nucleic Acids Research. 44 (9): 4025–4036. ISSN 1362-4962. PMC 4872111 Freely accessible. PMID 27067546. doi:10.1093/nar/gkw245.
  10. ↑ Starczynowski DT, Morin R, McPherson A, Lam J, Chari R, Wegrzyn J, Kuchenbauer F, Hirst M, Tohyama K, Humphries RK, Lam WL, Marra M, Karsan A (Jan 2011). "Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations". Blood. 117 (2): 595–607. PMID 20962326. doi:10.1182/blood-2010-03-277012.

Further reading

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