Mincle receptor

Macrophage inducible Ca2+-dependent lectin, (abbreviated to mincle), is a member of the C-type lectin superfamily encoded by the gene CLEC4E. It is a pattern recognition receptor that can recognize glycolipids including mycobacterial cord factor, trehalose-6,6'-dimycolate (TDM).[1][2] As a C-type lectin, the mincle receptor binds a range of carbohydrate structures, predominantly containing glucose or mannose, and play an important role in recognition of bacterial glycolipids by the immune system. Upon activation by cord factor, Mincle binds the Fc receptor FcRγ and Syk. Cord factor also binds and activates the related C-type lectin MCL.[3][4]

A wide range of ligands promote signalling through Mincle. These include glucose and trehalose mycolates, and their closely related corynomycolates from mycobacteria and corynebacteria.[5] Glycosyl diglycerides from various pathogenic and commensal bacteria and fungi such as Lactobacillus plantarum,[6] Streptococcus pneumoniae, Mycobacterium tuberculosis[7] and Malassezia sp. Crystalline cholesterol, cholesterol sulfate, and the protein SAP130 also signal through Mincle.

See also

References

  1. ↑ Moody, DB; Matsunaga, I (2009). "Mincle is a long sought receptor for mycobacterial cord factor.". Journal of Experimental Medicine. 206: 2879–88. PMC 2806465 Freely accessible. PMID 20008525. doi:10.1084/jem.20092533.
  2. ↑ Ishikawa, E; Ishikawa T; Morita YS; Toyonaga K; Yamada H; Takeuchi O; Kinoshita T; Akira S; Yoshikai Y; Yamasaki S (2009). "Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.". Journal of Experimental Medicine. 206: 2865–8. PMC 2806462 Freely accessible. PMID 20008526. doi:10.1084/jem.20091750.
  3. ↑ Miyake, Y; Toyonaga K; Mori D; Kakuta S; Hoshino Y; Oyamada A; Yamada H; Ono K; Suyama M; Iwakura Y; Yoshikai Y; Yamasaki S (2013). "C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.". Immunity. 38: 1050–1062. PMID 23602766. doi:10.1016/j.immuni.2013.03.010.
  4. ↑ Richardson, Mark B.; Williams, Spencer J. (2014-06-23). "MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns". Frontiers in Immunology. 5. ISSN 1664-3224. PMC 4066366 Freely accessible. PMID 25002863. doi:10.3389/fimmu.2014.00288.
  5. ↑ van der Peet, PL; Gunawan, C; Torigoe, S; Yamasaki, S; Williams, Spencer J (2015). "Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle". Chem. Commun. 51: 5100–5103. PMID 25714652. doi:10.1039/c5cc00085h.
  6. ↑ Shah, S; Nagata M; Yamasaki D; Williams SJ (2016). "Total synthesis of a cyclopropane-fatty acid α-glucosyl diglyceride from Lactobacillus plantarum and identification of its ability to signal through Mincle.". Chemical Communications. 52: 10902–1065. PMID 27533919. doi:10.1039/C6CC05631H.
  7. ↑ Richardson MB, S, S, SJ., MB; Torigoe, S; Yamasaki, S; Williams, SJ (2015). "Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: total synthesis and structure activity relationships". Chem. Commun. 51: 15027–30. PMID 26310657. doi:10.1039/c5cc04773k.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.