Minaprine

Minaprine
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration		 Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Biological half-life 2-2.5 hours
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.043.012
Chemical and physical data
Formula C17H22N4O
Molar mass 298.383 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Minaprine (INN, USAN, BAN) (brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions.[1]

A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats.[2] In a study it has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.[3]

References

  1. ↑ Fung, M.; Thornton, A.; Mybeck, K.; Wu, J. H.-h.; Hornbuckle, K.; Muniz, E. (1 January 2001). "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999". Therapeutic Innovation & Regulatory Science. 35 (1): 293–317. doi:10.1177/009286150103500134.
  2. ↑ Kan JP, Mouget-Goniot C, Worms P, Biziere K (1986). "Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat". Biochemical Pharmacology. 35 (6): 973–978. PMID 3954800. doi:10.1016/0006-2952(86)90085-7.
  3. ↑ Contreras JM, Rival YM, Chayer S, Bourguignon JJ, Wermuth CG (1999). "Aminopyridazines as acetylcholinesterase inhibitors". Journal of Medicinal Chemistry. 42 (4): 730–741. PMID 10052979. doi:10.1021/jm981101z.


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