Mikhail Blagosklonny
Mikhail Blagosklonny | |
---|---|
Fields | Anti-aging medicine, oncology |
Institutions | Roswell Park Cancer Institute |
Alma mater | First Pavlov State Medical University of St. Peterburg |
Mikhail Blagosklonny is a scientist who studies cancer and aging. He was formerly a professor of oncology at the Roswell Park Cancer Institute in New York.[1]
Career
Blagosklonny earned both his M.D. in internal medicine and his PhD in experimental medicine and cardiology from the First Pavlov State Medical University of St. Peterburg.[1] He was appointed associate professor of medicine at New York Medical College, Valhalla, NY in 2002 before taking a position as a senior scientist at Ordway Research Institute (Albany, New York). Blagosklonny held this position until 2009 when he was appointed professor of oncology at Roswell Park Cancer Institute.[1]
Blogosklonny's research interests include cancer and targeted cancer therapies that protect normal cells from damage, as well as the underlying mechanisms of aging (biogerontology) and anti-aging drugs.[1]
Rapamycin and aging
Blagosklonny has formulated a hypothesis about the possible role of TOR signaling in aging and cancer and proposed using rapamycin, a popular cancer drug as a possible treatment for life extension.[2] He is considered one of the most passionate advocates for rapamycin in longevity research.[3]
Editorial activities
Blagosklonny is editor-in-chief of Aging,[4] Cell Cycle,[5] and Oncotarget.[6] In addition, he is associate editor of Cancer Biology & Therapy[7] and a member of the editorial board of Cell Death & Differentiation.[8]
The reviewing process employed by Oncotarget has been criticized by Jeffrey Beall,[9] who also included Oncotarget and Aging on his list of "potential, possible, or probable predatory scholarly open-access journals"[10] in July 2015.[9] Further reports on Beall's blog suggest that the substandard peer review processes for these journals are used by their respective editor-in-chief to entice prospective authors to include references to Blagosklonny's own publications in their articles (following the peer review), thereby raising his personal impact factor.[11]
Selected publications
Blagosklonny has published over 270 papers in peer-reviewed journals with over 25,000 citations, giving him an h-index of 83.[12]
- Blagosklonny, MV (Dec 2013). "TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists". Nature Cell Death & Disease. 4: e964. PMC 3877573 . PMID 24336084. doi:10.1038/cddis.2013.506.
- Leontieva, OV; Demidenko, ZN; Blagosklonny, MV (Jun 2014). "Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program". PNAS. 111 (24): 8832–7. PMC 4066505 . PMID 24889617. doi:10.1073/pnas.1405723111.
- Hypoxia, Blagosklonny MV. (Feb 2013). "MTOR and autophagy: converging on senescence or quiescence". Autophagy. 9 (2): 260–2. PMC 3552896 . PMID 23192222. doi:10.4161/auto.22783.
- Leontieva, OV; Natarajan, V; Demidenko, ZN; Burdelya, LG; Gudkov, AV; Blagosklonny, MV (Aug 2012). "Hypoxia suppresses conversion from proliferative arrest to cellular senescence". PNAS. 109 (33): 13314–8. PMC 3421205 . PMID 22847439. doi:10.1073/pnas.1205690109.
- Leontieva, OV; Demidenko, ZN; Gudkov, AV; Blagosklonny, MV (2011). "Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin". PLoS One. 6 (10): e26126. PMC 3191182 . PMID 22022534. doi:10.1371/journal.pone.0026126.
- Demidenko, ZN; Fojo, T; Blagosklonny, MV (Apr 2005). "Complementation of two mutant p53: implications for loss of heterozygosity in cancer". FEBS Letters. 579 (10): 2231–5. PMID 15811347. doi:10.1016/j.febslet.2005.03.012.
- Blagosklonny, MV (2003). "Matching targets for selective cancer therapy". Drug Discov. Today. 8: 1104–7. PMID 14678733. doi:10.1016/s1359-6446(03)02806-x.
- Giannakakou, P; Nakano, M; Nicolaou, KC; O'Brate, A; Yu, J; Blagosklonny, MV; Greber, UF; Fojo, T (August 2002). "Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics". PNAS. 99: 10855–60. PMC 125062 . PMID 12145320. doi:10.1073/pnas.132275599.
- Blagosklonny, MV (2002). "Oncogenic resistance to growth-limiting conditions". Nature Reviews Cancer. 2: 221–5. PMID 11990858. doi:10.1038/nrc743.
- Blagosklonny, MV (Apr 2002). "STI-571 must select for drug-resistant cells but 'no cell breathes fire out of its nostrils like a dragon'". Nature Leukemia. 16 (4): 570–2. PMID 11960334. doi:10.1038/sj.leu.2402409.
- Blagosklonny, MV (Apr 2002). "Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs". Nature Leukemia. 16 (4): 455–62. PMID 11960322. doi:10.1038/sj.leu.2402415.
- Blagosklonny, MV. Pardee AB. (Mar 2002). "Conceptual biology: unearthing the gems". Nature. 416 (6879): 373. PMID 11919607. doi:10.1038/416373a.
- Blagosklonny, MV; Fojo, T; Bhalla, KN; Kim, JS; Trepel, JB; Figg, WD; Rivera, Y; Neckers, LM (2001). "The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy". Leukemia. 15: 1537–43. PMID 11587211. doi:10.1038/sj.leu.2402257.
- Blagosklonny, MV (2001). "Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells". Leukemia. 15: 936–41. PMID 11417480. doi:10.1038/sj.leu.2402127.
- Blagosklonny, MV (2001). "Unwinding the loop of Bcl-2 phosphorylation". Leukemia. 15: 869–74. PMID 11417471. doi:10.1038/sj.leu.2402134.
References
- 1 2 3 4 Roswell Park Cancer Center Mikhail Blagosklonny profile Page accessed November 30, 2016
- ↑ "A New Path to Longevity". Scientific American. 306: 32–39. 2011. doi:10.1038/scientificamerican0112-32. Retrieved 2016-11-20.
- ↑ "Does a Real Anti-Aging Pill Already Exist? Inside Novartis’s push to produce the first legitimate anti-aging drug, Business Week, 2015". Retrieved November 20, 2016.
- ↑ "Editorial Board". Aging. Retrieved 2016-11-20.
- ↑ "Editorial Board". Cell Cycle. Taylor & Francis. Retrieved 2016-11-20.
- ↑ "Editorial Board". Oncotarget. Retrieved 2016-11-20.
- ↑ "Editorial board". Cancer Biology & Therapy. Taylor & Francis. Retrieved 2016-11-20.
- ↑ "About the journal". Cell Death & Differentiation. Retrieved 2016-11-20.
- 1 2 Beall, Jeffrey (19 April 2016). "Oncotarget's Peer Review is Highly Questionable". Scholarly Open Access. WordPress.com. Archived from the original on 20 April 2016. Retrieved 2016-11-20.
- ↑ Beall, Jeffrey (2016-11-20). "LIST OF STANDALONE JOURNALS: Potential, possible, or probable predatory scholarly open-access journals". Scholarly Open Access. WordPress.com. Archived from the original on 2 December 2016. Retrieved 19 April 2016.
- ↑ "Mikhail Blagosklonny's Journal Aging: A Review". Scholarly Open Access. 6 December 2016. Archived from the original on 24 December 2016. Retrieved 17 January 2017.
- ↑ "Mikhail Blagosklonny". Google Scholar. Google. Retrieved 2016-11-20.